To evaluate the effects of YangXinShi tablet on multiple coronary artery disease with angina pectoris.Methods:A total of 76 patients who were diagnosed as multiple coronary artery disease in the hospital were randomly divided into control group and YangXinShi group.There were 38 cases in each group.After 12 weeks’ treatment，the clinical symptoms of angina pectoris，electrocardiogram，LVEF，Hcy，6-minute walk test and adverse reactions of all patients were detected.Results:After treatment，1)the total effective rate of relieving angina pectoris symptom in YangXinShi group(97.74%)was higher than that of control group(78.95%)and the difference was statistically significant(P<0.05)； 2)the improving rate of electrocardiogram in YangXinShi group(75.0%)was higher than that in control group(63.89%)and the difference was statistically significant(P<0.05)； 3)the LVEF in YangXinShi group(59±6.7)% was higher than that of in control group(53±7.1)% and the difference was statistically significant(P<0.05)； 4)the Hcy in YangXinShi group(8.3±0.46)μmol/L was lower than that in control group(9.7±0.48)μmol/L and the difference was statistically significant(P<0.05)； 5)the 6-min walk distance in YangXinShi group(526±57)m was higher compared with that of control group(463±52)m and the difference was statistically significant(P<0.05)； 6)the incidence of adverse reactions in YangXinShi group(5.26% was lower than that of control group(13.16%)and the difference was significant(P<0.05).Conclusion:YangXinShi tablet combined with western medicine on multiple coronary artery disease was better than the conventional western medicine treatment.