世界中医药

目的:观察复方六君子汤治疗急性放射性肺损伤的临床疗效。方法:将60例放射治疗后发生急性放射性肺损伤的胸部恶性肿瘤患者随机分为治疗组和对照组,每组30例。治疗组给予复方六君子汤和激素口服;对照组仅予以激素口服。分别于治疗前、治疗后4周、治疗后8周拍摄胸部X线片或者胸部CT。观察各时间点患者身体功能状态评分(卡氏评分)、呼吸困难状况评分(Watters评分)、中医症状评分和放射肿瘤协作组(RTOG)急性放射损伤分级并评价各时间点胸部X线片或胸部CT,依据临床症状和影像学变化判定疗效。结果:治疗组的卡氏评分、Watters评分、中医症状评分等较对照组改善明显(P<0.05),且治疗组较对照组显示出更好的缓解趋势。结论:复方六君子汤可以有效地治疗急性放射性肺损伤,缓解症状,改善患者生活质量。

English Summary:

To observe the effects of Compound Liujunzi Decoction treatment of acute radioactive lung injury.Methods:The patients(n=60)were randomly divided into treatment group and control group(each n=30).The treatment group was treated with Compound Liujunzi Decoction and orally taken hormone.Patients in the control group were treated with only orally-taking hormone.Chest X-ray films or chest CT were taken before treatment，at 4th week and 8th week after treatment.The Karnofsky scoring，Watters scoring and symptom of traditional Chinese medicine scoring，grading of radiation therapy oncology group(RTOG)standard were observed and evaluated at each point when patients having the chest X-ray or chest CT.According to the clinical symptoms and imaging changes，curative effects were measured.Results:Compared with the control group，the karnofsky scoring，watters scoring and symptoms of traditional Chinese medicine scoring improved obviously(P<0.05)，and the treatment group show better relieving trend than that of the control group.Conclusion:Compound Liujunzi Decoction may effectively control the acute radioactive lung injury，relieve symptoms and improve the quality of life of patients.

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