| 引用本文:李悦琳，刘勇，李继科，曾义岚，叶庆，王玥莲.中西医治疗流行性感冒轻症病例229例的临床对照研究[J].世界中医药,2016,(09):. |
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| 中西医治疗流行性感冒轻症病例229例的临床对照研究 |
| Clinical Control Study on 229 Cases of Epidemic Cold with Light Syndrome Treated with Chinese Medicine and Western Medicine |
| 投稿时间：2016-05-18 |
| DOI：10.3969/j.issn.1673-7202.2016.09.039 |
| 中文关键词: 中西医治疗 流行性感冒 轻症 对照研究 |
| English Keywords:Chinese and western medicine treatment Influenza Mild symptoms Control |
| 基金项目:“十二五”国家科技重大专项(编号:2012ZX10004301-002)——发热伴呼吸道症候群诊疗预案和临床救治研究;四川省卫生厅2013年度科技项目(编号:130432)——中医药、中西医结合治疗发热伴呼吸道症候群传染病的系统评价;成都市科技局2015年度科技项目(编号:2015-HM02-00006-SF)——川派中医名家传染病防治技术推广平台与应用效果研究;成都市卫生局2013年度科研项目(编号:2013020)——传染病专科医院建立中西医结合防治传染病的机制体系研究;成都市卫计委2015年度科技项目(编号:2015102)——川派中医名家传染病防治技术推广平台与应用效果研究 |
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| 中文摘要: |
| 目的:探讨中西医治疗流行性感冒轻症的临床特征、病情转归规律,比较中西医疗效的差异性和安全性,为治疗提供参考。方法:采用中央随机的方法,将229例流感轻症病例随机分为观察组（118例）和对照组（111例）,观察组患者采用基础治疗+中医治疗,对照组患者采用基础治疗+西医治疗,观察人口学指标、流行病学史、基础疾病、体温、症状、体征、实验室检查、胸部影像学检查和心电图等变化。结果:2组总体疗效比较,观察组患者痊愈率略高于对照组。观察组患者治愈89例(83.96%),好转17例(16.04%);对照组治愈79例(80.61%),好转19例(19.39%);总有效率100%。2组均无转为重症或死亡病例。2组退热起效时间和完全退热时间比较,观察组短于对照组,分别是(3 266.95±1 236.79)vs(3 346.25±1 384.12),(3 805.53±1 546.90)vs(3 892.60±1 709.02)。在第3天时观察组患者呼吸道症状缓解率较对照组高,为23.3% vs 13.72%,观察组患者症状缓解更快。研究过程中共报道不良事件5例,其中观察组3例(2.97%),对照组2例(2.06%),差异无统计学意义(P>0.05)。费用方面,2组检查项目相同,经5 d治疗的中药汤剂费用(为精品小包装中药价格,含熬药费)平均为131.78元/例,国产奥司他韦为168元/例,进口奥司他韦为264.97元/例,观察组患者费用明显低于对照组。结论:中医方案治疗流行性感冒轻症疗效与奥司他韦相当,在退热和缓解呼吸道症状方面有一定优势,且价格低廉、易于获取。 |
| English Summary: |
| To explore the clinical characteristics and the prognosis of the patients with mild symptoms of influenza，and to compare the differences and safety of Chinese and western medical treatment，and to provide reference for the treatment.Methods:A total of 229 patients with mild influenza were randomly divided into the experimental group and the control group.The experimental group received basic treatment with Chinese medicine treatment，control group was treated with basic and western medicine.The demographic indicators，epidemiological history，underlying diseases，body temperature，symptoms，signs，laboratory tests，chest image examination and electrocardiogram(ECG)were observed.Results:The curative rate of the experimental group was slightly higher than that of the control group.In the experimental group，89 cases(83.96%)were cured，17 cases improved(16.04%)； the control group were 79 cases(80.61%)and 19 cases(19.39%)respectively，the total effective rate was 100%.None of the two groups were transferred to severe or dead.As for the antipyretic effect and completely antifebrile time comparison，the results of the experimental group were shorter than that of the control group，respectively with （3 266.95±1 236.79） and （3 346.25±1 384.12），and （3 805.53±1 546.90） and （3 892.60±1 709.02）.At third days，the rate of relieving rate of respiratory symptoms in the experimental group was higher than that of the control group，and 23.3% vs 13.72%.In the study，5 cases of adverse events were reported，including 3 cases(2.97%)in experimental group and(2.06%)in control group.There was no significant difference between the two groups.The inspection procedure had the same cost，after 5 days’ treatment，the Chinese medicine decoction cost(for the small package of Chinese medicinals，including the brewing)131.78 yuan/case，domestic oseltamivir 168 yuan/case and foreign oseltamivir 264.97 yuan/case.The experimental group cost significantly less than the control group.Conclusion:Chinese medicine has similar efficacy with oseltamivir in treatment of mild influenza，and can also relieve fever and respiratory symptoms，and also is cheap and easy to access. |
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