To observe the clinical effect of Yao minority medical plaster at navel on patients with portal hypertensive gastropathy of cold and deficiency of spleen and stomach pattern.Methods:Sixty cases were randomly divided into treatment group and control group with 30 cases in each group. Both of the groups were treated with routine supportive medicine for inhibiting gastric acid secretion, controlling ventricular rate, vitamin supplementation, protecting liver and reducing enzyme, and treatment group additionally received treatment of Yao minority medical plaster at the same time. The symptom score, endoscopic features, portal venous hemodynamics indexes, and renal artery hemodynamics indexes were observed.Results:There was a significant difference between the two groups after the treatment in symptom score, clinical effect, endoscopic features, PCIII, and portal venous hemodynamics indexes(P<0.05).Conclusion:Yao minority medical plaster therapy may significantly improve the symptoms, gastric mucosal lesions, portal venous hemodynamics indexes and have significant efficacy compared with the control group.