To explore the clinical effect of integrated Chinese and western medicine in treatment of severe burn sepsis.Methods:A total of 80 cases of severe burn sepsis patients admitted during July 2013 to December 2015 were divided into observation group and control group according to the random sampling method，40 cases in each group.Patients in the control group were given anti-infection，fluid resuscitation，enteral and parenteral nutrition support，and treatment to correct water，electrolyte and acid-base balance disorders and so on，the observation group was treated with Chinese medicine intravenous drip combined with Chinese decoction on the basis of control group treatment.The clinical symptoms and laboratory indexes，effective rate of the two groups were observed and compared.Results:Before and after treatment，the CRP，TNF alpha，IL-6 and LPS were improved in both two groups.While the observation group had better results than the control group with significant differences(P<0.05)； the total effective rate of observation group(92.5%)was higher than that of the control group(77.5%)，the difference was statistically significant(P<0.05)； and two groups showed no adverse reactions.Conclusion:The clinical effect of integrated Chinese and western medicine in treatment of severe burn sepsis is better than that of simple western medicine treatment also with less adverse reactions.