Wumei pill is recorded in Shanghan Lun·Jueyin diseases. It is firstly used to treat ascariasis of biliary tract and Ludovic giuly. Ke Qin from Qing Dynasty regards that “Wumei pill can be used as a master medicine to treat Jueyin diseases”. Professor Liu Ximing argues that Wumei pill combines soreness, bitterness, pungency, coldness and heat, so it can co-regulate yin and yang, qi and blood, and both tonify healthy qi and purge dirty. It can be used when cold and heat pathogen attack Jueyin liver, when the coordination of the spleen and stomach was disrupted, or when cold, heat, excessiveness and deficiency mixed together. Also, it can be used in internal medicine, surgery, gynecology, and pediatrics. This paper discuss the nature of Jueyin diseases, the indications and composition principle of Wumei pill, the caution in using it and some examples of application to illustrate the experience of Liu Ximing in using Wumei pills.