To observe the clinical effects of acupotomy combined with ozone treatment of occipital nerve entrapment syndrome.Methods:Seventy-two patients with occipital nerve compress syndrome were randomly divided into control group and treatment group with 38 cases in the treatment group and 34 cases in the control group.The treatment group was intervened by acupotomy combined with ozone，while the control group was intervened by electro-acupuncture.The Visual Analogue Scale(VAS)and function evaluation of cervical spondylosis was used for the observation before and after intervention，and the efficacies were compared.Results:Twelve cases in the treatment group were cured，19 cases markedly effective，6 cases effective and 1 case invalid and the total efficiency was 97.4%.Six cases in the control group cured，12 cases markedly effective，11 cases effective，5 cases invalid and the total efficiency was 85.3%.After the treatment，VAS scores of the two groups were lower than before and the treatment group decreased more significantly.The differences showed statistically significant(P<0.05).The total effective rate of treatment group(97.4%)was significantly higher than that of the control group(85.3%)，and the difference was statistically significant(P<0.05).Conclusion:The acupotomy combined with ozone treatment for occipital nerve compressive syndrome is safe and effective，pain-relief time is short，and the clinical curative rate is better than that of electro-acupuncture treatment.This method is simple and has less complications and low treatment cost，which is worthy of clinical application.