世界中医药

目的：系统评价龙胆泻肝汤治疗单纯疱疹性角膜炎的临床疗效与安全性。方法：通过检索CNKI、Wan Fang Data、VIP等国内中文数据库自建库至2015年5月，明确公开发表使用龙胆泻肝汤治疗单纯疱疹性角膜炎的随机或半随机的临床对照试验的文献，将符合纳入标准的研究通过系统RevMan5.3统计学软件进行方法学质量评价、Meta-分析、漏斗图分析、异质性检验等分析方法统计数据。结果：12项符合纳入标准的研究，Meta-分析的结果显示,总有效率合并相对危险度(RR)及95%可信区间(CI值)为1.25（1.14,1.37）；疗程比较的RR（95%CI）值显示为1.74［1.37,2.21］；治疗时间比较的MD(95%CI)值为-2.61(-3.45,-1.77)。结论：龙胆泻肝汤联合基础治疗用于治疗单纯疱疹性角膜炎与单纯使用基础治疗相对比，具有较好的临床疗效性，且在症状改善、治疗后复发例数的减少以及缩短治病疗程周期等方面都具有显著优势，但由于所纳入的研究方法学的质量偏低，发生偏倚性较高，因此降低了该系统评价的安全可靠性，故需要更为合理的高质量临床试验方法来进行验证。

English Summary:

To systematically review the clinical efficacy and security of Longdan Xiegan decoction for herpes simplex keratitis.Methods:Retrieve the CNKI, Wan Fang Data and VIP database from foundation point to May, 2015 about Longdan Xiegan decoction in treating herpes simplex keratitis of randomized or semi-randomized controlled trials. Eligible studies were included, then the methodological quality of inclusive trails was assessed by Meta-analysis, funnel plot analysis, and heterogeneity test were adopted to analyze data by RevMan5.3 software.Results:A total of 12 trials of Meta analysis showed that the total efficiency value RR and 95% confidence interval value were1.25(1.14,1.37), course compared value RR and 95% confidence interval value were 1.74［1.37, 2.21］, compare of therapy time value were MD(95%CI)=-2.61(-3.45,-1.77).Conclusion:Compare Longdan Xiegan decoction and basic therapy with western medicine in treating herpes simplex keratitis, herbal medicine have the high curative effect, can improve the symptoms and signs, reduce recurrence cases and shorten cure time. It has obvious advantages, but the low quality of clinical research and happen partiality would influence reliability of the systematic review conclusion.

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