To investigate the difference of brain function activation mode between liver stagnation patients and healthy people while hearing cheerful music by using the blood oxygen level dependent functional magnetic resonance imaging (BOLD-FMRI) technique,which aims to reveal the pathology and physiology of liver depression syndrome from the perspective of photography.Methods:To choose 16 cases of patients with liver depression syndrome and no other confirmed disease.Also to choose 16 cases of normal people into control group,and match the age and gender with the patient group.Using block design,all the participants enjoy cheerful music while performing BOLD-FMRI examination.After statistics analysis,differences between activated brain regions and the activation patterns between liver depression syndrome group and the normal control group were discussed.Results:Liver depression syndrome group presented significant activation in bilateral middle frontal gyrus,bilateral parietal lobe,right cerebellum,and on the left cuneus and left cingulate cortex.Normal control group presented significant activation in the bilateral precuneus,precentral gyrus and postcentral gyrus,right paracentral lobule,left tongue gyrus and cuneus.The scope of activated brain regions is significantly smaller in liver depression syndrome group than the control group.Conclusion:The study found that liver depression syndrome patients and healthy people’s brain presented significant different activation pattern when in response to cheerful music,thus further confirming the abnormal brain pattern in patients with liver depression syndrome.Also,this provides objective evidence to clarify the pathogenesis of liver depression syndrome.