| 引用本文:刘明1，刘子旺2，赵晶1，陈云翔1，庞冉1，王志群1.肝郁症与正常人群欣赏欢快音乐的脑功能激活模式研究[J].世界中医药,2016,(09):. |
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| 肝郁症与正常人群欣赏欢快音乐的脑功能激活模式研究 |
| The Difference of Brain Function Activation Mode between Liver Stagnation Patients and Healthy People while Hearing Cheerful Music |
| 投稿时间：2015-09-06 |
| DOI：10.3969/j.issn.1673-7202.2016.09.069 |
| 中文关键词: 音乐欣赏 脑功能磁共振 肝郁证 |
| English Keywords:Music appreciation Brain Function MRI Liver depression syndrome |
| 基金项目:国家自然科学基金面上项目——基于磁共振关键技术的阿尔茨海默病脑网络异常和血流灌注相关性研究（编号：81370037）；北京市自然科学基金项目——阿尔茨海默病大脑半球间功能与结构连接异常模式及认知相关性研究（编号：7153166） |
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| 中文摘要: |
| 目的：探讨肝郁证(肝气郁结证)患者欣赏欢快音乐时血氧水平依赖脑功能磁共振成像（BOLD-fMRI)的激活模式，从影像学角度揭示肝郁证的病理生理机制。方法：选择确诊的肝郁证患者16例，均为典型单纯肝气郁结证、无其他兼证夹杂患者。正常对照组16例，年龄和性别与患者组匹配。实验方法采用组块设计，所有受试者欣赏欢快音乐同时，用BOLD-fMRI技术进行脑功能磁共振成像，经统计学处理后获取激活脑区，比较肝郁证组和正常对照组激活脑区的差异。结果：肝郁证组16例在大脑双侧额中回、双侧顶叶、右侧小脑、左侧楔叶和左侧扣带回等有显著激活。正常对照组在双侧楔前叶、双侧中央前回、双侧中央后回、右侧中央旁小叶、左侧舌回、左侧楔叶等有显著激活。肝郁证组激活脑区范围显著减少。结论：研究发现肝郁证患者与正常对照者欣赏欢快音乐时脑区激活模式比较有统计学意义，从而进一步证实肝郁证脑功能异常模式，为探明中医肝气郁结证的发病机制提供了客观证据。 |
| English Summary: |
| To investigate the difference of brain function activation mode between liver stagnation patients and healthy people while hearing cheerful music by using the blood oxygen level dependent functional magnetic resonance imaging (BOLD-FMRI) technique,which aims to reveal the pathology and physiology of liver depression syndrome from the perspective of photography.Methods:To choose 16 cases of patients with liver depression syndrome and no other confirmed disease.Also to choose 16 cases of normal people into control group,and match the age and gender with the patient group.Using block design,all the participants enjoy cheerful music while performing BOLD-FMRI examination.After statistics analysis,differences between activated brain regions and the activation patterns between liver depression syndrome group and the normal control group were discussed.Results:Liver depression syndrome group presented significant activation in bilateral middle frontal gyrus,bilateral parietal lobe,right cerebellum,and on the left cuneus and left cingulate cortex.Normal control group presented significant activation in the bilateral precuneus,precentral gyrus and postcentral gyrus,right paracentral lobule,left tongue gyrus and cuneus.The scope of activated brain regions is significantly smaller in liver depression syndrome group than the control group.Conclusion:The study found that liver depression syndrome patients and healthy people’s brain presented significant different activation pattern when in response to cheerful music,thus further confirming the abnormal brain pattern in patients with liver depression syndrome.Also,this provides objective evidence to clarify the pathogenesis of liver depression syndrome. |
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