| 引用本文:王一夫1，刘爽2.MAPKs信号通路与阿尔兹海默病的研究进展[J].世界中医药,2016,(09):. |
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| MAPKs信号通路与阿尔兹海默病的研究进展 |
| The Research Progress of Alzheimer’s Disease and MAPKs Signaling Pathways |
| 投稿时间：2015-12-14 |
| DOI：10.3969/j.issn.1673-7202.2016.09.073 |
| 中文关键词: MAPKs通路：阿尔兹海默病：研究进展 |
| English Keywords:MAPKs Signaling Pathways Alzheimer’s Disease Research Progress |
| 基金项目:国家自然科学基金项目——从调控ERK/MAPK信号通路探讨补肾法对阿尔茨海默病及骨质疏松症“异病同治”生物学机制研究（编号：81202652）；天津市应用基础及前沿技术研究计划——从ERK/MAPK通路探讨补肾法“异病同治”的生物学效应机制（编号：13JCQNJC11700） |
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| 中文摘要: |
| 丝裂原活化蛋白激酶(Mitogen-activated Protein Kinases，MAPKs)通路是广泛存在于哺乳细胞中的重要信号转导通路。其通路功能与细胞的增值、分化、转化及凋亡密切相关。阿尔兹海默病（Alzheimer’s Disease，AD）是一种起病隐匿、进行性发展的神经系统退行性疾病。其主要病理表现在于Aβ淀粉样蛋白沉积，老年斑形成以致的神经元损伤及死亡。故从MAPKs通路的角度对AD病理机制及治疗的基础研究已成为现代医学研究的一大热门。现对MAPKs通路与AD的现代医学研究简要综述。 |
| English Summary: |
| MAPKs pathways are important signal transduction pathways, which widely exist in mammalian cells. Its function is closely related to cell proliferation, differentiation, transformation and apoptosis. Alzheimer’s disease is a kind of nervous system degenerative disease, occult onset, progressive development. The major pathological manifestations are A beta amyloid, age spots formation caused neuron damage and death. So the basic researches of AD pathology mechanism and treatment from the angle of MAPKs pathway have become a hot modern medical research topic. This passage reviewed the researches of MAPKs pathways and AD pathology. |
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