| 引用本文:何勤思1，白桦2，郑智3.自噬在中医药治疗大肠癌中的作用研究[J].世界中医药,2016,(09):. |
|
| 自噬在中医药治疗大肠癌中的作用研究 |
| Autophagy Effect in Chinese Medicine Treatment in Colorectal Cancer |
| |
| DOI：10.3969/j.issn.1673-7202.2016.09.074 |
| 中文关键词: 大肠癌 自噬 中医药 |
| English Keywords:Colorectal cancer Autophagy Chinese Medicine |
| 基金项目:国家自然科学基金项目（编号：81260592）——p21WAF1/CIP1去泛素化介导复方浙贝颗粒逆转大肠癌化疗耐药的机制研究；江西省卫计委中医药科研基金项目（编号：2012A083）——益气散结法调节结、直癌化疗耐药患者miRNA-17-92表达的临床研究 |
|
| 摘要点击次数: 753 |
| 全文下载次数: 756 |
| 中文摘要: |
| 大肠癌是我国常见的恶性肿瘤之一，发病率和病死率逐年上升。目前，大肠癌的治疗多以手术治疗为主，但大多数患者发病时已属晚期，治疗及预后不佳。中医药在防治大肠癌的复发转移，改善患者生存质量方面具有较好的治疗优势，但临床治疗效果个体差异较大，作用机制和作用靶点仍有待进一步明确。近年来研究表明，细胞自噬在肿瘤发生、发展中扮演重要角色，也成为目前抗肿瘤治疗的研究热点［1］，本文对中医药通过自噬作用抗大肠癌的研究进行综述，为中医药防治大肠癌的研究提供依据和参考。 |
| English Summary: |
| Colorectal cancer is one of the common malignant tumor diseases in digestive system with the increasing of morbidity and mortality in China.Currently，the surgery is still a unique treatment for the colorectal cancer.The prognosis of colorectal cancer is mainly associated with the disease stage.However，many patients are not diagnosed until in advance stage，and the treatment is not always satisfactory in those patients.Chinese medicine has a unique advantage in preventing recurrence and metastasis of the cancer and keeping patients’ life quality.But it differs among patients.And its mechanism and targets should be explored in further depth.In recent years，researches have shown that Chinese medicine treatment played an important role in the tumor growth and metastasis，making it a heated research topic.This paper reviewed the effect of Chinese medicine via autophagy in treating the cancer so as to provide evidence for clinical treatment of the cancer. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
