In recent years，several kinds of pre-clinical and clinical molecule medicine were organized into categories with different regulating mechanisms and therapeutic effects on methicillin resistant Staphylococcus aureus (MRSA). And the number of studies on active constituent in Chinses material medica is growing, and indicated that large amount of Chinese material medica inhibited growth of drug-resistance bacteria both in component and by using separately, to prevent resistant mechanism and the evolution of the bacteria. The purpose of this review was to discuss the mechanisms of molecules currently and Chinese material medica on anti-MRSA properties via analysis.