Acinetobacter baumannii is an important pathogenic bacteria causing infectious diseases in hospital. It shows multi drug resistance and pan drug resistance against antibiotics. The treatment of diseases caused by this bacteria is very difficult to given as its drug resistance mechanism is complex. Traditional Chinese Medicine had significant antibacterial effect of antibacterial, proved in long term of application. Further researches on resistance of bacteria with TCM is meaningful. This article is a review on drug resistance mechanism of Acinetobacter baumannii and related researches of Traditional Chinese Medicine to be the basis of Acinetobacter baumannii infection control.