| 引用本文:孔令博1，郭玉红2，付跃峰1，李艳鹏1，牛丽强1，杨雪冬1，姜旭1，刘佳莹1，刘清泉2.芪归银方对多重耐药铜绿假单胞菌感染大鼠血清IL-1β水平的影响[J].世界中医药,2016,(10):. |
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| 芪归银方对多重耐药铜绿假单胞菌感染大鼠血清IL-1β水平的影响 |
| The Impact of Qiguiyin Decoction on IL-1β in Serum of Multi-drug Resistant Pseudomonas Aeruginosa Infected Rats |
| 投稿时间：2016-09-12 |
| DOI：10.3969/j.issn.1673-7202.2016.10.007 |
| 中文关键词: 扶正透邪 芪归银方 多重耐药菌感染 炎性反应因子 IL-1β |
| English Keywords:Fuzheng touxie Qiguiyin Decoction Multi-drug resistant pseudomonas aeruginosa infection Inflammatory factor Interleukin-1β |
| 基金项目:北京中医药大学基本科研业务费项目（编号：2015-JYB-JSMS057）；国家“十二五”科技重大专项（编号：2013ZX09102026） |
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| 中文摘要: |
| 目的:探讨芪归银方对多重耐药铜绿假单胞菌感染大鼠血清IL-1β水平的影响。方法:将SD大鼠随机分为空白组、模型组、西药对照组、芪归银方组、中西医结合组5组，运用ELISA检测采用不同干预方法的各组大鼠血清IL-1β水平，比较各组之间的差异。结果:模型组大鼠血清IL-1β水平在各时间点均较空白组明显升高，差异有统计学意义（P<0.01）；西药对照组、芪归银方组、中西医结合组大鼠血清IL-1β水平在3 h、8 h、24 h较空白组明显升高，差异有统计学意义（P<0.01）；西药对照组、芪归银方组、中西医结合组大鼠血清IL-1β水平在72 h、5 d较空白组无统计学意义（P>0.05）；西药对照组大鼠血清IL-1β水平在72 h、5 d较模型组降低，差异有统计学意义（P<0.01）；扶正透邪方组大鼠血清IL-1β水平在24 h较模型组升高，差异有统计学意义（P<0.05），在5 d较模型组降低，差异有统计学意义（P<0.01）；中西医结合组大鼠血清IL-1β水平在24 h较模型组升高，在72 h、5 d较模型组降低，差异均有统计学意义（P<0.01）。结论:与抗生素相比，芪归银方能够在炎性反应早期增强促炎递质的释放，二者联用则作用更明显，有利于积极清除细菌及毒素，并随着时间的推移，使促炎递质的释放迅速下降，维持正常炎性反应水平以免太长的过激炎性反应不利于损伤的修复，充分体现了“阴平阳秘”“以平为期”的中医理论。 |
| English Summary: |
| To explore the impact of qiguiyin decoction on IL-1β in serum of multi-drug resistant pseudomonas aeruginosa infection rats.Methods:SD rats were randomly divided into blank group, model group, western medicine control group, qiguiyin decoction group, and integrated Traditional Chinese Medicine and western medicine group. Level of IL-1β in rats was detected by ELISA, and then the differences between groups were compared.Results:The level of IL-1β in model group was significantly higher than that of blank group, with statistically significant difference (P<0.01). The levels of IL-1β in western medicine control group, qiguiyin decoction group, and integrated Traditional Chinese Medicine and western medicine group at 3 h、8 h、24 h were significantly higher than those of blank group, and the difference was statistically significant(P<0.01). The levels of IL-1β in western medicine control group, qiguiyin decoction group, and integrated Traditional Chinese Medicine and western medicine group at 72 h、5 d showed no statistically significant difference when comparing with those of blank group(P>0.05). The levels of IL-1β in control group at 72 h、5 d were lower than model group, the difference was statistically significant(P<0.01). The level of IL-1β in qiguiyin decoction group at 24 h was significantly higher than that of model group, and the difference was statistically significant(P<0.05). The level of IL-1β in qiguiyin decoction group at 5 d was lower than that of model group, and the difference was statistically significant(P<0.01). The level of IL-1β in integrated Traditional Chinese Medicine and western medicine group at 24 h was significantly higher than model group, and the difference was statistically significant(P<0.01). The level of IL-1β in integrated Traditional Chinese Medicine and western medicine group at 72 h、5 d were lower than model group, and the difference was statistically significant(P<0.01).Conclusion:Compared with antibiotics ,qiguiyin decoction increased the release of pro-inflammatory medium in early inflammatory response. The efficacy of antibiotics combined with qiguiyin decoction was more obvious, which removed bacteria and toxins while the release of pro-inflammatory medium dropping rapidly over time to keep normal inflammatory response level for repairing damage. And it indicated Chinese medicine theories, yin and yang in equilibrium, to achieve balance. |
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