To explore the impact of qiguiyin decoction on IL-1β in serum of multi-drug resistant pseudomonas aeruginosa infection rats.Methods:SD rats were randomly divided into blank group, model group, western medicine control group, qiguiyin decoction group, and integrated Traditional Chinese Medicine and western medicine group. Level of IL-1β in rats was detected by ELISA, and then the differences between groups were compared.Results:The level of IL-1β in model group was significantly higher than that of blank group, with statistically significant difference (P<0.01). The levels of IL-1β in western medicine control group, qiguiyin decoction group, and integrated Traditional Chinese Medicine and western medicine group at 3 h、8 h、24 h were significantly higher than those of blank group, and the difference was statistically significant(P<0.01). The levels of IL-1β in western medicine control group, qiguiyin decoction group, and integrated Traditional Chinese Medicine and western medicine group at 72 h、5 d showed no statistically significant difference when comparing with those of blank group(P>0.05). The levels of IL-1β in control group at 72 h、5 d were lower than model group, the difference was statistically significant(P<0.01). The level of IL-1β in qiguiyin decoction group at 24 h was significantly higher than that of model group, and the difference was statistically significant(P<0.05). The level of IL-1β in qiguiyin decoction group at 5 d was lower than that of model group, and the difference was statistically significant(P<0.01). The level of IL-1β in integrated Traditional Chinese Medicine and western medicine group at 24 h was significantly higher than model group, and the difference was statistically significant(P<0.01). The level of IL-1β in integrated Traditional Chinese Medicine and western medicine group at 72 h、5 d were lower than model group, and the difference was statistically significant(P<0.01).Conclusion:Compared with antibiotics ,qiguiyin decoction increased the release of pro-inflammatory medium in early inflammatory response. The efficacy of antibiotics combined with qiguiyin decoction was more obvious, which removed bacteria and toxins while the release of pro-inflammatory medium dropping rapidly over time to keep normal inflammatory response level for repairing damage. And it indicated Chinese medicine theories, yin and yang in equilibrium, to achieve balance.