To discuss the effect of Ginseng and Poria Stomach Capsule on gastrointestinal reaction and immune function in patients with breast cancer receiving chemotherapy.Methods:A total of 132 patients with breast cancer were selected and divided randomly into capsule group and control group，66 in each group.The control group patients received Azasetron(10 mg/time，1 / d，intravenous infusion given for 7 days after chemotherapy)，capsule group patients received Ginseng and Poria Stomach Capsule(2 pills /time，3 times/d，to oral taken for 7 days after chemotherapy).The CD3，CD4，CD8 levels were evaluated by flow cytometer.The(QLQ C30)scale was used to assess quality of life after 1，3，7 d′s treatment of all patients.Results:The gastrointestinal adverse reactions of the capsule group were significantly lower than the control group(P<0.05）； CD3，CD4，CD4/CD8 levels of the capsule group were significantly better than control group(P<0.05）； QLQ C30 score of the capsule group after 1，3，7 d′s treatment were significantly lower than the control group(P<0.05）.Conclusion:Ginseng and Poria Stomach Capsule can effectively reduce the gastrointestinal adverse reaction of breast cancer patients in chemotherapy period and enhance the immunity function of the patients，as well as improve patient′s quality of life and clinical curative effect.