世界中医药

目的:观察康莱特注射液在提高根除术或综合治疗后的非小细胞肺癌(Non-small Cell Lung Cancer,NSCLC)患者临床疗效及其免疫力方面的效果和作用机制。方法:选取2015年8月至2016年1月收住我科的根除术或综合治疗后的NSCLC患者90例,随机分成对照组和观察组,每组45例。对照组采用葡萄糖注射液250 mL静脉推注,2次/d,持续15 d。观察组予康莱特注射液静脉滴注,2次/d,同样治疗15 d后观察2组治疗的临床疗效、各免疫因子评分、药物不良反应、临床受益情况分析及血浆IL-2、IL-6、IL-10及TNF-α水平变化等情况。结果:1)治疗后观察组有效率86.67%,对照组有效率68.89%,2组有效率比较差异有统计学意义(P<0.05);2)2组患者治疗前各免疫功能比较,差异无统计学意义(P>0.05),治疗15 d后,观察组各免疫动能均较治疗前稍提高,但对照组较治疗前无变化,差异有统计学意义(P<0.05);3)2组患者治疗过程中均出现不同程度的不良反应,比如可表现为腹痛、腹泻、恶心、呕吐、白细胞、血小板、血红蛋白减少等,对照组出现1例(2.22%),观察组2例(4.44%),观察组不良反应与对照组比,差异无统计学意义,与葡萄糖注射液相比,该药不会增加患者用药不良反应(P>0.05)。观察组KPS和体重变化的稳定率和改善例数明显高于对照组(P<0.05);4)2组患者治疗前血浆IL-2、IL-6、IL-10及TNF-α水平比较差异无统计学意义(P>0.05)。治疗15 d后,上述指标均较治疗前下降,但观察组下降更明显。结论:康莱特注射液可明显改善NSCLC患者手术或放、化疗后免疫力,效果显著,同时可提高其临床疗效,且不良反应及药物不良反应并不升高,值得推广。

English Summary:

To observe the effect of the Kanglaite Injection in treatment of non-small cell lung cancer, and to discuss the regulation of T lymphocyte subsets. Methods:A total of 90 cases of non-small cell lung cancer in our department from August 2015-January 2016, were randomly divided into control group and observation group, 45 cases in each group. The control group received glucose injection of 250 mL twice a day. Observation group were given the Kanglaite Injection twice a day. After 15 days of treatment, the clinical efficacy, all immune factors score, adverse reactions, clinical benefit analysis and serum IL-2, IL-6, IL-10 and TNF-α level changes were compared. Results:1)After treatment, the effective rate of observation group was 86.67%, the control group 68.89%, the difference was significant (P<0.05）；2) Before treatment, there was no significant difference on immune function between the two groups(P>0.05), after 15 days′ treatment, the immunized kinetic energy of observation group slightly improved, but control group had no changes, the difference was statistically significant (P<0.05）；3) During the treatment, patients in both two groups experienced different adverse reactions, such as abdominal pain, diarrhea, nausea, vomiting, white blood cells, platelets, hemoglobin and reduction, there was one case (2.22%)in the control group and two cases (4.44%) in observation group, the difference was not statistically significant, showing that the medicine did not increase the side effects (P>0.05). There were significantly more cases that experienced KPS and body weight changes in the observation group than control group (P<0.05）； 4) Before treatment, there were no differences on plasma IL-2, IL-6, IL-10 and TNF-α level between two groups(P>0.05). But after 15 days′ treatment, the index decreased, and the observation group decreased more significantly. Conclusion:Kanglaite Injection can significantly improve the immunity of non-small cell lung cancer patients with surgery, radiotherapy and chemotherapy, with significant effect and less adverse reactions, which is worth promoting.

查看全文查看/发表评论下载PDF阅读器