世界中医药

目的：探讨中药健脾益胃汤治疗慢性萎缩性胃炎（Chronic Atrophic Gastritis，CAG）的疗效。方法：将108例CAG患者按数字随机表法分为2组，每组54例，治疗组采用中药健脾益胃汤治疗，对照组采用胃苏颗粒治疗，比较2组治疗前后中医证候积分和血清白细胞介素-8（Interleukin-8，IL-8）、白细胞介素-11（Interleukin-11，IL-11）、肿瘤坏死因子-α（Tumor Necrosis Factor-α，TNF-α）、生长激素（Growth Hormone，GH），并比较2组中医证候疗效和胃镜疗效。结果：治疗前2组脾虚湿热瘀血证各项中医证候积分和血清IL-8、IL-11、TNF-α和GH水平差异均无统计学意义（P>0.05），治疗后2组上述指标均显著改善（P<0.01），研究组改善情况均优于对照组（P<0.01），差异均有统计学意义，治疗后治疗组中医证候疗效和胃镜疗效均优于对照组（P<0.05），差异均有统计学意义。结论：中药健脾益胃汤组方治疗CAG疗效显著，尤其适于基层医院推广营养。

English Summary:

To observe the clinical effect of Jianpi Yiwei decoction in the treatment of chronic atrophic gastritis (CAG).Methods:A total of 108 patients with CAG were divided into two groups according to the random number table,with 54 cases in each group.The experimental group were treated with Jianpi Yiwei decoction,and the control group took Weisu granule.Scores of TCM syndromes and serum interleukin (IL)-8,IL-11,tumor necrosis factor alpha (TNF alpha),growth hormone (GH) before and after treatment were compared between the two groups,and TCM syndromes and the efficacy of endoscopy were compared.Results:There were no statistical significant differences in the spleen deficiency and dampness heat and blood stasis TCM syndrome score and serum IL-8,IL-11,TNF-and GH levels of the two groups (P>0.05) before treatment,while after treatment,the indexes mentioned above in the two groups were significantly improved (P<0.01).Besides,the improvement of the study group were higher that of the control group,and the differences were statistically significant (P<0.01).The TCM syndromes and endoscopy efficacy of the experimental group after treatment were better than those of the control group (P<0.05).Conclusion:The curative effect of Jianpi Yiwei decoction in treatment of CAG is significant,so it is especially recommended to be promoted in primary hospital.

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