To observe the clinical effect of Jianpi Yiwei decoction in the treatment of chronic atrophic gastritis (CAG).Methods:A total of 108 patients with CAG were divided into two groups according to the random number table,with 54 cases in each group.The experimental group were treated with Jianpi Yiwei decoction,and the control group took Weisu granule.Scores of TCM syndromes and serum interleukin (IL)-8,IL-11,tumor necrosis factor alpha (TNF alpha),growth hormone (GH) before and after treatment were compared between the two groups,and TCM syndromes and the efficacy of endoscopy were compared.Results:There were no statistical significant differences in the spleen deficiency and dampness heat and blood stasis TCM syndrome score and serum IL-8,IL-11,TNF-and GH levels of the two groups (P>0.05) before treatment,while after treatment,the indexes mentioned above in the two groups were significantly improved (P<0.01).Besides,the improvement of the study group were higher that of the control group,and the differences were statistically significant (P<0.01).The TCM syndromes and endoscopy efficacy of the experimental group after treatment were better than those of the control group (P<0.05).Conclusion:The curative effect of Jianpi Yiwei decoction in treatment of CAG is significant,so it is especially recommended to be promoted in primary hospital.