| 引用本文:聂颖颖，周景想，姜婷，宋业琳，迟伟峰，王阔.补肾活血汤剂辅助治疗高血压早期肾损害的疗效观察[J].世界中医药,2016,(10):. |
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| 补肾活血汤剂辅助治疗高血压早期肾损害的疗效观察 |
| Clinical Efficacy of Bushen Huoxue Decoction in Treatment of Early Renal Damage in Patients with Essential Hypertension |
| 投稿时间：2015-12-22 |
| DOI：10.3969/j.issn.1673-7202.2016.10.022 |
| 中文关键词: 补肾活血汤 高血压早期肾病损害 疗效 肾功能 β2微球蛋白 MAlb 血脂 |
| English Keywords:Bushen Huoxue Decoction Early-stage kidney damage along with hypertension Efficacy Renal function β2-microglobulin MALb Lipid |
| 基金项目:青岛市2011年度中医科研计划项目（编号：2011-zyy012）——补肾活血法对实验高血压大鼠血管重塑影响的研究 |
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| 中文摘要: |
| 目的：探讨补肾活血汤剂辅助治疗高血压早期肾损害的疗效，以及对肾功能、β2微球蛋白、MAlb及血脂的影响。方法：92例高血压早期肾损害患者依据随机数字表法随机分为观察组46例与对照组46例。对照组采用常规治疗，观察组在对照组基础上结合补肾活血汤治疗。2组疗程均为12周。比较2组治疗总有效率，治疗前后肾功能指标、β2微球蛋白、MAlb、血脂指标、24 h血压变化及不良反应观察。结果：观察组总有效率（91.30%）高于对照组（73.91%）（P<0.05）；2组Scr、BUN水平治疗后降低（P<0.05）；观察组Scr、BUN水平治疗后低于对照组（P<0.05）；2组β2微球蛋白、MAlb水平治疗后降低（P<0.05）；观察组β2微球蛋白、MAlb水平治疗后低于对照组（P<0.05）；2组血脂指标TC、TG、LDL-C、HDL-C水平治疗前后比较差异无统计学意义（P>0.05）；2组24 h SBP和DBP治疗后明显下降（P<0.05）；观察组24 h SBP和DBP治疗后低于对照组（P<0.05）；2组均未见严重药物不良反应。结论：补肾活血汤剂治疗高血压早期肾损害患者疗效显著，可降低患者β2微球蛋白、MAlb水平，改善肾功能，但对血脂功能无影响，且安全可靠，具有重要研究价值。 |
| English Summary: |
| To investigate the clinical efficacy of Bushen Huoxue Decoction in treatment of early renal damage in patients with essential hypertension and its effect on the renal function, β2 microglobulin, MALb and lipid. Methods: Ninety-two patients with early kidney damage along with hypertension were divided into observation group (n=46) and control group (n=46) according to random number table. Patients in the control group were treated with conventional treatment and those in the observation group were additionally treated with Bushen Huoxue Decoction compared with the control group. Patients in the two groups received 12-week treatment. The total effective rate was compared between the two groups and the indexes of renal function, 2 microspheres protein, MAlb, blood lipid, 24 h blood pressure changes and adverse reactions were observed before and after treatment. Results: The total effective rate in the observation group (91.30%) was significantly higher than that of the control group (73.91%) (P<0.05); the Scr and BUN level in both groups were significantly decreased after the treatment (P<0.05) and those in the observation group were significantly lower than those of the control group (P<0.05). The β2-microglobulin and MALb levels in both the groups were significantly decreased (P<0.05) after treatment which were significantly lower than those of the control group (P<0.05). The ipid index levels, namely TC, TG, LDL-C and HDL-C, of both the groups showed no significant difference before and after treatment (P>0.05). The 24 h SBP and DBP in both the groups were significantly decreased after treatment (P<0.05) and the 24 h SBP and DBP in observation group were significantly lower than those of the control group (P<0.05). There were no serious adverse drug reactions in both groups during the treatment course. Conclusion: The clinical efficacy of Bushen Huoxue Decoction in treatment of early renal damage in patients with essential hypertension is significant, safe and reliable and may reduce the β2-microglobulin and MALb levels, and improve the renal function. There was no effect on the blood-fat, providing a significant research value. |
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