To observe and analyze the clinical effect of integrated traditional Chinese and Western medicine on treatment of acute severe pancreatitis. Methods:From March 2012 to March 2016, 58 cases of acute severe pancreatitis patients were randomly divided into control group and observation group, each of 29 cases. Patients in the control group were given conventional treatment of anti infection, fluid infusion, and fasting, while the observation group was givenall the above treatment as well as traditional Chinese medicine treatment. The two groups of patients were compared, after treatment, in clinical indicators, laboratory indexes and the efficiency of treatment, the incidence of complications. Results:After treatment, the improvement of the observation group in the clinical symptoms and the index are better than that of the control group. For observation group, the total efficiency (86.2%) was significantly higher than that of the control group (58.6%). And compared with the control group, the mods, renal failure, abdominal infection, operation and the number of death cases in the control group were higher than those of the observation group with statistical significance (P<0.05). Conclusion:Integrated Traditional Chinese and Western medicine treatment of severe acute pancreatitis was better than simply using western medicine in aspects of fast recovery, good curative effect, less complications, safety and efficiency, and it worth popularization and application.