| 引用本文:吴瑞锋，马胜利，于乐.六味地黄丸对肾阴虚型骨质疏松老年患者骨钙素及骨密度的影响[J].世界中医药,2016,(10):. |
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| 六味地黄丸对肾阴虚型骨质疏松老年患者骨钙素及骨密度的影响 |
| The Impact of Six-Ingredient Rehmannia Pill on Osteocalcin and Bone Mineral Density in Patients with Kidney Yin Deficiency Type Senile Osteoporosis |
| 投稿时间：2016-06-16 |
| DOI：10.3969/j.issn.1673-7202.2016.10.028 |
| 中文关键词: 骨质疏松 肾阴虚型 六味地黄丸 骨钙素 骨密度 |
| English Keywords:Osteoporosis, Kidney yin deficiency type, Six-Ingredient Rehmannia Pill, Osteocalcin Bone mineral density |
| 基金项目:陕西省科技计划项目(编号:2014K11-01-01-18) |
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| 中文摘要: |
| 目的:观察六味地黄丸对肾阴虚型骨质疏松老年患者的疗效及其对骨钙素、骨密度的影响。方法:选取我院2012年1月至2014年1月收治的70例肾阴虚型骨质疏松老年患者纳入研究,随机分为对照组和观察组,其中对照组每周口服1次阿仑膦酸钠,70 mg/次,观察组在对照组治疗方案基础上加用六味地黄丸,1丸/次，2次/d。2组均以28 d为1个疗程,连续使用6个疗程,检测治疗前后患者骨钙素、骨密度水平的变化情况。并用生活质量量表(36-items Short form Health Survey Scale,SF-36)评估患者治疗后的生活质量。结果:1)观察组SF-36量表中8个维度评分均明显提高,与治疗前及对照组治疗后比较,差异均有统计学意义(P<0.01)。2)2组治疗后第1-4腰椎(L1-L4)和股骨颈、总髋部的骨密度与治疗前相比均具统计学意义(P<0.05),其中观察组治疗后骨密度远高于对照组(P<0.05);对照组与观察组在治疗后的t值均显著高于治疗前(P<0.05),且观察组显著高于对照组(P<0.05);3)2组治疗后外周血清骨钙素的浓度均有上调,与治疗前比较差异有统计学意义(P<0.05),其中观察组上调的趋势较对照组明显,差异有统计学意义(P<0.05)。结论:六味地黄丸可能通过骨密度及骨钙素的合成来改善肾阴虚型骨质疏松患者的生活质量。 |
| English Summary: |
| To observe the curative effect of Six-Ingredient Rehmannia Pill on the patients with kidney yin deficiency type senile osteoporosis and its influence on osteocalcin and bone mineral density. Methods:A total of 70 cases of the patients with kidney yin deficiency type senile osteoporosis in our hospital were randomly divided into the control group and the observation group, the control group had oral alendronate once a week, 70 mg each time, the observation group had Six-Ingredient Rehmannia Pill on the basis treatment of the control group, 1 pill at a time, twice a day. Both of the two groups had 28 days′ treatment, continuous six courses of treatment, osteocalcin and bone mineral density changes were detected before and after treatment. And quality of life scale (36-items short form health survey scale, SF-36) was adopted to evaluate the quality of live on the patients after treatment. Results:1) Eight dimensions of SF-36 scale scores in the observation group were significantly improved, compared with before treatment and the control group after the treatment, the differences were with significant statistical significance (P<0.01). 2) BMD of lumbar spine（L1-L4）, the femoral neck, and total hip of the two groups after treatment were statistical different compared with before treatment (P<0.05), bone mineral density of the observation group were much higher than the control group after treatment (P<0.05); T value in the control group and the observation group after treatment were significantly higher than before treatment (P<0.05), and the observation group were significantly higher than control group (P<0.05); 3) The peripheral blood concentration of osteocalcin raised significantly in the two groups after treatment, (P<0.05), the results in the observation group was significantly better than the control group (P<0.05). Conclusion:Six-Ingredient Rehmannia Pill can improve quality of life in the patients with kidney yin deficiency type osteoporosis, by the synthesis of bone mineral density and osteocalcin. |
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