| 引用本文:任景，李涛，于苗，智勇.针灸联合独活寄生汤治疗膝关节骨性关节炎疗效观察及对微炎性反应指标的影响[J].世界中医药,2016,(10):. |
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| 针灸联合独活寄生汤治疗膝关节骨性关节炎疗效观察及对微炎性反应指标的影响 |
| Acupuncture Combined with Pubescent Angelica and Taxillus Decoction in Treatment of Knee Osteoarthritis and Its Clinical Effect on Micro Inflammatory Index |
| 投稿时间：2016-01-10 |
| DOI：10.3969/j.issn.1673-7202.2016.10.048 |
| 中文关键词: 针灸 独活寄生汤 膝骨性关节炎 疗效 微炎性反应指标 |
| English Keywords:Pubescent Angelica and Taxillus Decoction Acupuncture Knee osteoarthritis Curative effect Inflammation indexes |
| 基金项目:新疆维吾尔自治区自然科学基金项目——大灸治疗变应性鼻炎药物处方和穴位组合的优化研究（编号：2013211A115) |
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| 中文摘要: |
| 目的：探讨针灸联合独活寄生汤治疗膝关节骨性关节炎疗效及对微炎性反应指标的影响。方法：膝关节骨性关节炎患者92例按照随机数字表法随机分为治疗组（n=46）与对照组（n=46）。治疗组采用针灸联合独活寄生汤治疗，对照组采用西药治疗。2组疗程均为8周。比较2组治疗疾病和症候总有效率，治疗前后关节肿胀指数、关节压痛指数、炎性反应因子水平变化，治疗期间不良反应发生情况。结果：治疗组疾病治疗总有效率（93.48%）高于对照组（73.91%）（P<0.05）；治疗组症候治疗总有效率（95.65%）高于对照组（71.74%）（P<0.05）；2组关节肿胀指数、关节压痛指数治疗后明显降低（P<0.05）；治疗组关节肿胀指数、关节压痛指数低于对照组（P<0.05）；2组血清IL-1β、IL-6、hs-CRP水平治疗后明显降低（P<0.05）；治疗组血清IL-1β、IL-6、hs-CRP水平低于对照组（P<0.05）；治疗组不良反应发生率低于对照组（P<0.05）。结论：针灸联合独活寄生汤治疗膝关节骨性关节炎疗效显著，可明显降低患者血清IL-1β、IL-6、hs-CRP水平，改善微炎性反应状态，具有重要研究价值。 |
| English Summary: |
| To investigate the effect of acupuncture combined with Pubescent Angelica and Taxillus Decoction in the treatment of knee osteoarthritis and its clinical effect on micro inflammatory index.Methods:Total 92 knee osteoarthritis patients were randomly divided into treatment group (n=46) and control group (n=46).The treatment group was treated by acupuncture combined with Pubescent Angelica and Taxillus Decoction,the control group western medicine.The course of treatment was 8 weeks in two groups.The total effective rate,the effective rate of the symptoms,the joint swelling index,joint tenderness index,and the level of inflammatory factors and adverse reactions during treatment were compared between the two groups before and after the treatment.Results:The total effective rate of the treatment group (93.48%) was higher than that of the control group (73.91%) (P<0.05); The total effective rate of symptoms in treatment group (95.65%) was higher than that of control group (71.74%) (P<0.05); The joint swelling index,joint tenderness index decreased significantly in the two groups after treatment (P<0.05); The joint swelling index,joint tenderness index in the treatment group were lower than those in the control group (P<0.05); The serum levels of IL-1β,IL-6 and hs-CRP decreased significantly after treatment in both two groups (P<0.05); The levels of serum IL-1β,IL-6 and hs-CRP in the treatment group were lower than those in the control group (P<0.05); The rate of adverse reaction in the treatment group was lower than that of the control group (P<0.05).Conclusion:Acupuncture and moxibustion combined with Angelica parasitic Decoction treatment is effective in knee osteoarthritis with significant reducing effect in serum IL-1β and IL-6,hs CRP level and improvement in the micro inflammatory state,which has the important research value. |
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