世界中医药

目的：运用Meta分析方法，通过对疏血通联合硫辛酸治疗糖尿病周围神经病变的临床效果进行系统评价以指导临床用药。方法：全面检索疏血通联合硫辛酸治疗糖尿病周围神经病变的文献，并按照文献选择标准进行筛选，对疏血通联合硫辛酸及单用硫辛酸治疗糖尿病周围神经病变的文献进行Meta分析。结果：通过对6篇文献，614例患者的分析，结果提示疏血通联合硫辛酸组的总体有效率明显高于单用硫辛酸组（RD=0.19，95%CI［0.13,0.25］，P<0.01)。结论：疏血通联合α-硫辛酸相比单用α-硫辛酸能有效缓解糖尿病周围神经病变症状。但由于入选文献存在的方法学问题，有可能影响研究结果的真实性，有待进一步设计严谨的大样本、多中心、随机对照临床试验进行验证。

English Summary:

Using Meta analysis of shuxuetong combine with α-lipoic acid clinical effect on treatment of diabetic peripheral neuropathy by systematic review.And the analysis of the results guides clinical medication options.Methods:“Diabetic neuropathy”，“α-lipoic acid” and “Shuxuetong” were adopted as the search terms for comprehensive search in databases.Meta analysis was applied for literature relevant to Shuxuetong combined with α-lipoic acid therapy and α-lipoic acid therapy in the treatment of diabetic peripheral neuropathy.Results:Six papers including 614 patients with diabetic peripheral neuropathy were analyzed and the valid rate of α-lipoic acid treatment group was significantly higher than that of the control group(RD=0.19，95%CI ［0.13,0.25］，P<0.01).Conclusion:Shuxuetong combine with α-lipoic acid，compared with single α-lipoic acid therapy may effectively relieve the symptoms of diabetic peripheral neuropathy.As issues existed in methodology for the selection of literature，authenticity of the results may be affected.Rigorous，large sample，multi-center，randomized，controlled clinical trial will be further designed to validate the study.

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