To analyze the clinical characteristic, endoscope examination results and pathology of 100 cases of protuberant erosive gastritis and to provide more clinical information. Methods:Appropriate patients were selected and given endoscope examination and rapid urease test, and 2-4 pieces of mucosa at the most obvious part of protuberant erosion for biopsy. At the same time, pathological examination was also started, and the data was analyzed. Results:There were 68 cases (68%) with HP infection in all. And 16 cases (16%) had single protuberant erosive focus, while 84 cases (84%) multiple, P<0.05.In 63 (63%) cases, the focuses were at antrum of stomach, of which 53 cases (84%) are with HP infection; in 10 cases (10%), the focuses were at gastric body， of which none are with HP infection; in 27 cases (27%), the focuses were at body and antrum of stomach, of which 15 cases (56%) are with HP infection. The difference of comparison between various focused and between diverse HP infection had significance in statistic, (P<0.05).There was inflammation in 74 cases (74%); 39 (39%) were with intestinal metaplasia, among which 31 cases were HP positive (79%); 21 (21%) were with atrophy, among which 17 cases were HP positive (81%); 13 (13%) were with intraepithelial neoplasia, among which 31 cases were HP positive (79%), all elementary neoplasia. Conclusion:It was that different pathogenic positions were because of various mechanisms, and that those at the antrum of stomach are mainly the results of HP infection while others may be allergy and Immunology. As to those who were with intestinal metaplasia or atrophy and intraepithelial neoplasia, it was better to have eradication HP treatment in time.