世界中医药

目的：对100例隆起糜烂性胃炎的临床特点、胃镜检查结果及病理及进行分析，为临床提供更多的资料。方法：选取符合条件的患者，进行胃镜检查及快速尿素酶检测，对隆起糜烂最为明显的部位活检2~4块黏膜，及时送病理检查，对数据进行统计分析。结果：所选患者中存在HP感染的为68例(68%)。隆起糜烂病灶单个为16例(16%)，多个为84例(84%)，P<0.05。病灶位于胃窦部63例(63%)，其中存在HP感染为53例(84%)；病灶位于胃体部10例(10%)，均无HP感染；病灶位于胃窦胃体部27例(27%)，存在HP感染为15例(56%)，不同部位发病率比较及不同部位HP感染比较差异均有统计学意义(P<0.05)。炎性反应活动74例(74%)；伴有肠上皮化生39例(39%)，其中HP阳性者为31例（79%）；萎缩21例(21%)，其中HP阳性者为17例（81%）；伴有上皮内瘤变13例(13%)，低级别上皮内瘤变13例(13%)，其中HP阳性者为11例（85%），高级别上皮内瘤变0例。结论：推测不同部位发病机制有所不同，胃窦部主要为HP感染，余部位者则可能与免疫变态反应关系密切。对HP感染且伴有肠上皮化生或萎缩、上皮内瘤变者，应及时进行HP根除治疗。

English Summary:

To analyze the clinical characteristic, endoscope examination results and pathology of 100 cases of protuberant erosive gastritis and to provide more clinical information. Methods:Appropriate patients were selected and given endoscope examination and rapid urease test, and 2-4 pieces of mucosa at the most obvious part of protuberant erosion for biopsy. At the same time, pathological examination was also started, and the data was analyzed. Results:There were 68 cases (68%) with HP infection in all. And 16 cases (16%) had single protuberant erosive focus, while 84 cases (84%) multiple, P<0.05.In 63 (63%) cases, the focuses were at antrum of stomach, of which 53 cases (84%) are with HP infection; in 10 cases (10%), the focuses were at gastric body， of which none are with HP infection; in 27 cases (27%), the focuses were at body and antrum of stomach, of which 15 cases (56%) are with HP infection. The difference of comparison between various focused and between diverse HP infection had significance in statistic, (P<0.05).There was inflammation in 74 cases (74%); 39 (39%) were with intestinal metaplasia, among which 31 cases were HP positive (79%); 21 (21%) were with atrophy, among which 17 cases were HP positive (81%); 13 (13%) were with intraepithelial neoplasia, among which 31 cases were HP positive (79%), all elementary neoplasia. Conclusion:It was that different pathogenic positions were because of various mechanisms, and that those at the antrum of stomach are mainly the results of HP infection while others may be allergy and Immunology. As to those who were with intestinal metaplasia or atrophy and intraepithelial neoplasia, it was better to have eradication HP treatment in time.

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