世界中医药

作者	单位
郝二伟1,2,3，邓家刚2，侯小涛2，杜正彩2，吴航宣2，缪剑华3	1 广西药用植物园，南宁，530000； 2 暨南大学生物医学工程博士后流动站，广州，510632； 3 广西中医药大学广西中药效筛选重点实验室，南宁，530001

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中文摘要:

文章主要通过文献研究的方法，对复方益智颗粒治疗老年性痴呆的有效成分进行了归纳和分析。结果表明，人参皂苷Rb1、Rd、Re、Rg1、Rg2、Rg3，能通过不同的分子机制对Aβ引起的神经细胞毒性起到抑制作用；三七皂苷R1、R2、R4、R6、Fa，也具有减轻细胞对Aβ的神经毒性反应和促进细胞突起生长的作用，对老年性痴呆的病理发展有拮抗作用；绞股蓝皂苷III、IV、Ⅻ、X、Ⅰ、A-AH，可以明显提高模型小鼠的学习记忆能力，改善海马胆碱能系统功能，对诱导Aβ的AD细胞模型具有保护作用；淫羊藿苷对Aβ25-35所致神经细胞损伤具有保护作用，有利于老年性痴呆的治疗；原儿茶酸具有良好的神经保护作用；桑椹花色苷和氧化白藜芦醇都对神经系统有良好的保护作用。研究结果提示，皂苷类和黄酮类成分有可能是复方益智颗粒治疗老年性痴呆的物质基础，可为后续该制剂治疗老年性痴呆物质基础的研究奠定基础。

English Summary:

This passage summarized and analyzed the effective ingredients of treating Alzheimer’s disease of Fufang yizhi granule by literature research. The results showed that ginsenosideRb1, Rd, Re, Rg1, Rg2, Rg3 of Panax ginseng C.A. may have inhibition effect on the nerve cell toxicity caused by protein Aβ by different molecular mechanism; notoginsenosideR1, R2, R4, R6, Fa could relieve cell response to neurotoxicity of Aβ, and promote the outgrowth of neurites, have antagonism on the pathological development of Alzheimer’s disease; Gynostemma saponins III, IV, Ⅻ, X,Ⅰ, A-AH could obviously enhance the ability of learning and memory of mouse, improve the function of the hippocampus cholinergic system, and had the protection effect in AD cell model induced by Aβ; icariin had the protection effect in AD cell model induced by Aβ, which benefited for the treatment of AD; protocatechuic acid, mulberry anthocyanins, oxyresveratrol had the good protection effect on nervous system. The results of the study suggest that saponins and flavonoid are the main ingredients of Fufang yizhi Granule for treating Alzheimer’s disease, which lays as foundation for the further study of this product on the material basis.

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