| 引用本文:周樱1，祖冬梅1，王丕进2，贺玉红2，王晋超3.玉液汤对糖尿病性黄斑水肿的疗效观察及机制探讨[J].世界中医药,2016,(11):. |
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| 玉液汤对糖尿病性黄斑水肿的疗效观察及机制探讨 |
| Clinical research on the method of yuye tang in the therapy of diabetic macular edema and the mechanism |
| 投稿时间：2016-02-15 |
| DOI：10.3969/j.issn.1673-7202.2016.11.015 |
| 中文关键词: 玉液汤 糖尿病性黄斑水肿 临床疗效 IL-6 VEGF |
| English Keywords:Yuye Tang Diabetic macular edema Clinical effect IL-6 VEGF |
| 基金项目:新疆卫生厅医学联合基金项目(编号:2015211C209) |
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| 中文摘要: |
| 目的:观察玉液汤对糖尿病性黄斑水肿的临床疗效及其与IL-6、VEGF的影响。方法:将60例糖尿病性黄斑水肿患者随机分成2组,治疗组给予玉液汤+激光光凝治疗,对照组予激光光凝治疗,观察治疗4周后2组视力、视网膜厚度、视网膜血管情况等;应用ELISA检测2组患者血清中IL-6、VEGF含量表达情况。结果:2组经不同方法治疗4周后视力、视网膜厚度、视网膜血管情况比较差异有统计学意义(P<005),治疗组经玉液汤口服治疗与对照组比较,IL-6、VEGF的血清含量情况明显低于对照组,差异有统计学意义(P<005)。结论:玉液汤治疗糖尿病性黄斑水肿可以有效提高视力、改善视网膜厚度、视网膜血管情况,是一种安全有效的治疗方式,值得临床推广应用,而调节IL-6和VEGF可能是玉液汤发挥治疗作用的重要靶点。 |
| English Summary: |
| In the present study,we aimed to to observe the clinical curative effect of Yuye tang in the therapy of diabetic macular edema(DME)and investigate the relationship between this effect and IL-6 and VEGF.Methods:A total of 56 patients DME were randomly divided into into 2 groups,28 patients in treatment group were treated with modified Yuye Tang and laser photocoagulation of macular,28 patients in control group were treated with only laser photocoagulation of macular.Observe visual acuity,retinal macular thickness and ocular hemodynamic situation of the two groups after treatment of 4 weeks.The expression of IL-6 and VEGF was assessed by ELISA.Results:Significant differences were observed in terms of intraocular pressure,visual acuity,retinal macular thickness and ocular hemodynamic situation(P<005).Compared with the control group,the expression of IL-6 and VEGF level in the treatment group were significantly decreased(P<005).Conclusion:Yuye Tang in the treatment of DME can effectively control the improve eyesight,retinal macular thickness and ocular hemodynamic situation,is a kind of safe and effective treatment,worthy of clinical popularization and application,adjust the IL-6 and VEGF may be Yuye Tang give play to the important targets of therapy effect. |
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