To probe the clinical effect of Activating Blood and Removing Stasis Method by Qimai Tongluo Decoction on lower extremity arteriosclerosis obliterans patients. Methods: Lower extremity arteriosclerosis obliterans of 60 cases during September 2013 and May 2015 in our hospital were randomly divided into treatment group and control group by single blinded method, with 30 cases in each group. There were 16 female cases in the treatment group and 14 male; the average age is (56.08±9.71) years; and 15 famle and male cases in the control group; the average age (56.98±9.43) years old. The two groups had no statistically significant differences in age, gender (P>005), which was comparable. The control group was given basic treatment and alprostadil treatment; treatment group basic treatment and Qimai Tongluo Decoction. The venous blood, hemorheology, blood glucose and blood lipid before and after treatment; lower extremity ultrasound in superficial femoral artery and dorsalis pedis artery blood flow, blood vessel diameter and peak velocity were compared before and after treatment. Results: Except for the increased HDL level(P<005), the levels of FBG, PG, 2 h the TG, TC, and LDL decreased significantly in both two groups (P<005). But the treatment group had better results on FBG, 2 h, TG, TC, PG, LDL as well as HDL compared with the control group, difference was statistically significant(P<005). The average level of blood rheology dropped in both two groups after the treatment(P<005); and treatment group experienced obvious decrease in plasma viscosity, whole blood high shear viscosity, whole blood viscosity in cutting and whole blood viscosity low cut level; After treatment, femoral superficial artery and dorsalis pedis artery blood flow, blood vessel diameter rose in the two groups after the treatment (P<005), peak flow velocity became slower (P<005); compared with the control group, there was a significant increase in femoral superficial artery and dorsalis pedis artery blood flow, blood vessel diameter and decrease in slow peak velocity in the treatment group (P<005) Conclusion: Qimai Tongluo Decoction can improve the blood circulation through the method of Activating Blood and Removing Stasis in lowering extremity arterial occlusive disease, and improving blood hypercoagulability, which has curative effect.