世界中医药

目的：探讨消疣汤内服复合咪喹莫特外用治疗扁平疣的临床效果及对患者免疫功能的影响。方法：将2014年2月至2015年10月间收治的50例扁平疣患者分为观察组及对照组，观察组给予消疣散复合咪喹莫特治疗，对照组口服阿昔洛韦片联合咪喹莫特涂抹，统计调查临床治疗疗效、不良反应、血清中sIL-2R水平和IL-2水平、复发率。结果：观察组临床有效率显著高于对照组（P<005）；2组患者不良反应差异无统计学意义（P>005）；治疗后患者血清中IL-2水平显著升高（P<005），且观察组患者显著低于对照组（P<005）；2组sIL-2R水平均显著降低（P<005），且观察组显著高于对照组（P<005）；对照组患者复发率显著高于观察组（P<005）。结论：采用内服消疣汤联合外用咪喹莫特治疗扁平疣后，可以有效提高临床疗效，降低不良反应及复发率，并提高患者免疫功能，值得在临床工作中进行推广应用。

English Summary:

To discuss clinical effect of Xiaoyou Decoction combined with Imiquimod on treatment of verruca plana and patients’ immune function.Methods:Fifty cases of verruca plana from February 2014 to October 2015 were randomly divided into observation group and control group.The observation group were given Xiaoyou Decoction combined with Imiquimod，and the control group oral acyclovir tablets combined with Imiquimod applied externally.The clinical curative effect，adverse reaction and sIL-2R and IL-2 levels in serum and recurrence were statistics that investigated in the research.Results:The clinical effectiveness of the observation group was significantly better than that of the control group(P<005).Adverse reactions of the 2 groups had significant difference(P>005).After the treatment，sIL-2 levels in serum of all patients increased notably，and that of the observation group was markedly lower(P<005)； level of IL-2R in serum of the 2 groups decreased dramatically(P<005)，and the observation group was greatly higher，comparatively(P<005)； the recurrence rate of control group was much higher than the observation group(P<005).Conclusion:By use of Xiaoyou Decoction combined with Imiquimod on treatment of verruca plana，the clinical curative effect was effectively improved，adverse reactions and the recurrence rate reduced，the patients’ immune function improved.It deserved popularization and application in clinical work.

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