世界中医药

目的:本研究以淡渗利湿法立论,旨在初步评价其在治疗慢性肾炎蛋白尿以及预防肾脏纤维化的作用,为慢性肾炎蛋白尿的治疗提供有效方法。方法:选取济宁市中医院住院收治的慢性肾炎患者56例,随机分为观察组和对照组,每组28例;对照组采用氯沙坦钾治疗,观察组在对照组治疗的前提下,联合淡渗利湿中药方治疗6个月后,采用酶联免疫吸附法测定血清LN、CIV、TIMP-1指标的值,全自动生化仪测定24 h尿蛋白定量。比较2组治疗前、后以及2组间血清LN、CIV、TIMP-1指标以及24 h尿蛋白定量的变化。结果:2组治疗后的24 h尿蛋白定量均较治疗前明显减少,血清LN、CIV、TIMP-1水平较治疗前减少差异有统计学意义(P<005)。观察组治疗后LN、CIV、TIMP-1水平较对照组明显减少(P<005)。结论:淡渗利湿法联合氯沙坦钾治疗慢性肾炎合并蛋白尿患者,可以明显减少蛋白尿,对于预防肾间质纤维化具有一定的临床意义。

English Summary:

To evaluate the effect of inducing diuresis with bland drugs in treating chronic nephritis albuminuria and its function of preventing renal fibrosis. Methods: Fifty-six patients with chronic nephritis were randomly divided into Chinese medicine (CM) group and western medicine (WM) group with 28 cases in each group. WM group was treated with losartan potassium 100 mg/d, while CM group was treated with prescription with the function of inducing diuresis combined with losartan. After 6 months treatment, 24-hour urine protein, the value of serum laminin (LN), type IV collagen (CIV), and tissue inhibitor of matrix metallo proteinase-1 (TIMP-1) were compared between the two groups. Results: 24-hour urine protein of the both groups decreased obviously after treatment compared with that before the treatmrnt (P<005). The level of LN, CIV and TIMP-1 after the treatment decreased obviously compared with those before the treatmrnt (P<005). The level of LN, CIV and TIMP-1 of CM group decreased obviously compared with those of the WM group (P<005). Conclusion: Treatment of inducing diuresis with bland drugs may reduce 24-hour urine protein effectively compared with western medicine and possibly prevent fibrosis of kidney interstitium.

查看全文查看/发表评论下载PDF阅读器