引用本文:朱奇,康静波,李建国,齐文杰,孙涛.复方红豆杉联合体部伽玛刀治疗局部晚期胰腺癌临床研究[J].世界中医药,2016,(11):. |
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复方红豆杉联合体部伽玛刀治疗局部晚期胰腺癌临床研究 |
Clinical Research of Fufanghongdoushan Capsule Combined with γ-ray Stereotactic Body Radiation Therapy in Treatment of Locally Advanced Pancreatic Cancer |
投稿时间:2016-07-08 |
DOI:10.3969/j.issn.1673-7202.2016.11.034 |
中文关键词: 复方红豆杉胶囊 体部伽玛刀 胰腺癌 |
English Keywords:Fufanghongdoushan capsule γ-ray Stereotactic Body Radiation Therapy Pancreatic cancer |
基金项目:首都医学发展科研基金项目(编号:2009-3083) |
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中文摘要: |
目的:探讨复方红豆杉胶囊(Fufanghongdoushan capsule)联合体部伽玛刀(γ-ray Stereotactic Body Radiation Therapy,γ-SBRT)对局部晚期胰腺癌的治疗效果及安全性。方法:2013年8月至2014年9月海军总医院肿瘤诊疗中心收治的48例局部晚期胰腺癌患者,随机分为2组。研究组25例,采用体部伽玛刀治疗,PTV覆盖95%以上临床靶体积(Clinical Target Volume,CTV),等剂量曲线为50%~60%,单次周边剂量30~45 Gy,治疗10~11次,同时给予复方红豆杉胶囊06 g,3次/d,21 d为1个周期,治疗后继续口服5个周期,共6个周期。对照组23例,单纯行体部伽玛刀治疗。评价治疗效果及不良反应。结果:2组完全缓解率分别为286%和185%;研究组有效率为913%,对照组有效率为636%。2组中位无进展生存期(PFS)分别为10个月和6个月。2组不良反应相似,胃肠道反应发生率分别为826%和682%,骨髓抑制发生率分别为783%和636%。结论:复方红豆杉胶囊配合体部伽玛刀治疗局部晚期胰腺癌可提高局部控制率和有效率,且不良反应的耐受性良好。 |
English Summary: |
To evaluate the clinical toxicity and efficacy of Fufanghongdoushan capsule combined with γ-ray Body Stereotactic Radiation Therapy in treatment of locally advanced pancreatic cancer. Methods: A total of 45 patients with locally advanced pancreatic cancer were randomized into two groups. The combination group received γ-ray Stereotactic Body Radiation Therapy which was given isodose curve of 50%~60%, tumor encircling dose of 30~45 Gy per fraction, 10~11 fractions. Combined with Fufanghongdoushan capsule 06 g,three times a day for consecutive 21 days for six courses. And the control group was with γ-ray Stereotactic Body Radiation Therapy only. Toxicities and effects were evaluated according to the criteria of WHO and RTOG. Results: The CR in combination group and control group were 286% and 185% respectively(P>005). Response rate of combination group was 821% and 741% in control group(P>005). Two groups of the median progression-free surial (PFS) were 10 months and 6 months respectively; The rate of gastrointestinal tract side reaction in combination group and control group were 826% and 682%,myelosuppression in combination group and control group were 783% and 636%,respectively. Conclusion: Fufanghongdoushan capsule combined with body gamma system treatment can improve local control rate and effective rate for inoperable patients with local advanced pancreatic carcinoma, and adverse reaction is well tolerated. |
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