| 引用本文:黄志军1,2，梁鹏1，余黎3，李霞2，肖飞2，赵刚2.小金胶囊药材组分过敏性研究[J].世界中医药,2016,(11):. |
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| 小金胶囊药材组分过敏性研究 |
| Hypersusceptibility Study of Chinese Materia Medica Xiaojin Capsule |
| 投稿时间：2016-09-22 |
| DOI：10.3969/j.issn.1673-7202.2016.11.049 |
| 中文关键词: 小金胶囊 药材 过敏性 大鼠 RBL-2H3细胞 |
| English Keywords:Xiaojin capsule Chinese Materia Medica Hypersusceptibility Rat RBL-2H3 cell |
| 基金项目:2016年国家中医药管理局中药标准行动计划:小金胶囊标准化建设 |
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| 中文摘要: |
| 目的:探讨小金胶囊主要药材组分的过敏性。方法:实验分为12组,包括空白对照组、阳性对照组和10组不同药材组,通过灌胃方式对大鼠给药,隔天1次,15 d后取抗血清,对RBL-2H3细胞进行培养,进行抗原攻击后,检测培养液中组胺和β-氨基己糖苷酶的释放量。结果:制木鳖子组的细胞组胺释放量明显高于空白对照组(P<005),人工麝香组、制木鳖子组和乳没组的细胞β-氨基己糖苷酶释放量明显高于空白对照组,但自制木鳖子组和制乳没组的细胞组胺和β-氨基己糖苷酶释放量与空白对照组差异无统计学意义。结论:小金胶囊致敏药材可能为人工麝香、木鳖子和乳没,经适当方法炮制可降低其致敏性。 |
| English Summary: |
| To investigate the hypersusceptibility of Chinese Materia Medica Xiaojin Capsule.Methods:Blank control, positive control, and 10 groups of Chinese medicinal materials were set to fulfill the study. Drugs were orally administered every other day for 3 times. Serum was collected on 15 days after the first administration and used to bring up RBL-2H3 cells. Histamine and β-hexosaminidase were detected for hypersusceptibility evaluation.Results:Histamine release from RBL-2H3 cell of Cochinchina Momordica Seed group was obviously higher than that of blank group (P<005). β-hexosaminidase release by RBL-2H3 cell of artificial musk group, Cochinchina Momordica Seed group, frankincense and myrrh group was higher than that of blank. However, there was no statistical difference between blank and processed products of Cochinchina Momordica Seed, frankincense and myrrh.Conclusion:The sensitized Materia Medica in Xiaojin capsule may be artificial musk, cochinchina momordicae seed, frankincense and myrrh. The appropriate processing methods can be used to reduce the sensitization. |
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