| 引用本文:许海燕1，郑伶俐2.Box-Behnken优化咳露口服液提取工艺[J].世界中医药,2016,(11):. |
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| Box-Behnken优化咳露口服液提取工艺 |
| Optimization of Extraction Process of Kelu Oral Liquid by Box-Behnken |
| 投稿时间：2016-03-03 |
| DOI：10.3969/j.issn.1673-7202.2016.11.059 |
| 中文关键词: 咳露口服液 响应曲面法 提取工艺 黄芩苷 |
| English Keywords:Kelu Oral liquid Response surface methodology Extraction process Baicalin |
| 基金项目:陕西国际商贸学院校级科研项目（编号：SMXY201301）——咳露口服液絮凝—高速离心技术的研究 |
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| 中文摘要: |
| 目的：利用响应面法（RSM）优化咳露口服液的提取工艺。方法：以处方中君药黄芩的主要成分黄芩苷为优化指标，在单因素试验基础上，选取提取时间、提取次数、料液比为自变量，以水为提取溶剂，黄芩苷含量为响应值，应用中心组合试验设计方法，研究各自变量及其交互作用对黄芩苷含量的影响，建立二次多项回归方程预测数学模型。结果：提取时间、提取次数、料液比3个因素对黄芩苷含量均有显著影响。确定咳露口服液提取的最佳工艺参数提取时间70 min，提取次数2次，料液比1:13，在此条件下，口服液中黄芩苷的含量为096 mg/mL。结论：响应面法可用于咳露口服液提取工艺的优化，该方法快速、简单、稳定，对口服液提取工艺优化有一定参考价值。 |
| English Summary: |
| Response surface methodology（RSM）was used to optimize the extraction process of Kelu oral liquid.Methods:Among the prescription，Scutellaria Baicalensis was the principal drug，and the main component，baicalin，was the index of quality control.Based on the single factor analysis，the extraction time，extraction frequency and solid-to-liquid ratio were independent variables，and the amount of baicalinwasresponse value.The research center combined the design of the experiment，studied each independent variable and its interaction effect on the amount ofbaicalin and builded Second-degree polynomials equation mathematical model of prediction.Results:The extraction time，extraction frequency and solid-to-liquid ratio had all significant effects on the amount of baicalin.The optimal technology parameters extraction time of Kelu oral liquid was 70 min，the extraction times was 2 times，and solid-liquid ratio was 1:13Under such conditions，the amount of baicalinwas 096 mg/mL.Conclusion:Box-Behnken could be used for extraction optimization of extraction process for Kelu oral liquid，and the optimized technology was quick，simple and stable，besides，it had reference value for optimization of extraction of oral liquid. |
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