| 引用本文:贾明月1，韩桂玲1，张纾难1，于美丽2.中药治疗慢性阻塞性肺病TGF-β1、ET的系统综述[J].世界中医药,2016,(11):. |
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| 中药治疗慢性阻塞性肺病TGF-β1、ET的系统综述 |
| Treatment of Chronic Obstructive Pulmonary TGF-β1 and ET by Chinese Medicine: A Systematic review |
| 投稿时间：2016-06-06 |
| DOI：10.3969/j.issn.1673-7202.2016.11.075 |
| 中文关键词: 中药 慢性阻塞性肺病 TGF-β1 ET 系统综述 |
| English Keywords:Chinese herbal medicine Chronic Obstructive Pulmonary Disease TGF-β1 ET Systematic review |
| 基金项目: |
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| 中文摘要: |
| 目的:系统评价中药治疗对慢性阻塞性肺病患者转化生长因子β1(TGF-β1)、内皮素(ET)的临床疗效。方法:检索6个中英文数据库,检索时间截止至2016年4月,对符合的随机对照试验采用RevMan 53软件进行数据分析。结果:中药联合西医常规治疗对照西医常规治疗的Meta分析显示:联合中药组对TGF-β1改善情况优于西医常规治疗组,差异具有统计学意义(MD=-2969,95%CI［-4416,-1521］,P<0000 01,I2=98%,随机效应模型,260例,4项研究);中药干预组对ET水平的改善也较对照组明显,差异有统计学意义(MD=-77,95%CI［-1097,-443］,P<0000 01,I2=80%,随机效应模型,304例,5项研究)。结论:本研究提示中药治疗对慢性阻塞性肺病患者炎性反应因子TGF-β1及ET具有一定在改善作用,但由于纳入研究质量偏低,尚不能得出肯定结论,有待于开展多中心、大样本、高质量的随机对照试验进一步加以验证。 |
| English Summary: |
| To evaluate the efficacy of Chinese medicine(CM) on TGF-β1 and ET of Chronic Obstructive Pulmonary Disease(COPD) systematically.Methods:Six electronic databases, either Chinese or English, were searched for randomized controlled trials (RCTs) published until April 2016 RevMan 53 was used to analysis the data of the included RCTs.Results:Compared with a conventional therapy used alone, treatment with CM as an additional intervention was more effective on TGF-β1 (mean difference (MD)=-2969, 95% confidence interval (CI)=(-4416,-1521),P<000001, I2=98%, random effects model, 260 cases, 4 studies) and so as to that of ET ［MD=-77, 95%CI=(-1097,-443),P<000001, I2=80%, random effects model, 304 cases, 5 studies］.Both of the difference were statistically significant.Conclusion:CM improved TGF-β1 and ET of COPD. Considering the inherent limitations of the included studies, multicenter and larger high-quality RCTs should be performed to validate these findings in the future. |
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