| 引用本文:刘金岩1，王燕1，王斌1，高明2，迟国华1.“止痢颗粒”治疗小儿急性细菌性腹泻的临床疗效观察[J].世界中医药,2016,(12):. |
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| “止痢颗粒”治疗小儿急性细菌性腹泻的临床疗效观察 |
| Clinical Efficacy and Safety of Zhili Granule in Treatment of Children with Acute Clinical Bacterial Diarrhea |
| 投稿时间：2016-03-28 |
| DOI：10.3969/j.issn.1673-7202.2016.12.017 |
| 中文关键词: 细菌性腹泻 小儿 止痢颗粒 安全性 |
| English Keywords:Bacterial diarrhea Children Zhili Granule Safety |
| 基金项目:新疆维吾尔自治区人民医院院内项目(编号：20130258) |
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| 中文摘要: |
| 目的:探讨“止痢颗粒”治疗小儿急性细菌性腹泻的临床疗效和安全性。方法：收集2015年2月至2015年7月期间来我院治疗的急性细菌性腹泻患儿共120例，随机分为对照组和治疗组，每组60例，2组患儿均根据病情给予口服微生态制剂、蒙脱石散剂、补充多种维生素等措施在内的常规治疗，治疗组在常规治疗基础上给予“止痢颗粒”，连续治疗3 d，比较2组患儿止泻时间、体温恢复正常时间、症状体征消失时间及临床疗效、不良反应情况。结果：治疗组腹泻患儿止泻时间、体温恢复正常时间、症状体征消失时间均少于对照组，差异有统计学意义（P<0.05）。治疗组显效率为70.00%，总有效率为93.33%，对照组为31.67%、70.00%，治疗组显效率、总有效率均高于对照组，差异有统计学意义（P<0.05），2组均无严重不良反应发生。结论：急性细菌性腹泻患儿在常规治疗的基础上给予“止痢颗粒”治疗疗效确切，止泻、退热及症状体征消失时间更短，不增加不良反应，安全有效，可在临床推广应用。 |
| English Summary: |
| To investigate the clinical efficacy and safety of the children with acute bacterial diarrhea when treated with Zhili Granule. Methods: A total of 120 children with acute bacterial diarrhea were collected from May 2013 to December 2015 in our hospital, all the patients were randomly divided into the control group and the observation group, and 60 cases in each group. Based on the illness state, all the patients of two groups were given oral probiotics, montmorillonite powder, vitamins and other supplements conventional treatment, the observation group was given Zhili Granule on the basis of conventional therapy, the treatment lasted for 3 days. Time duration of stopping diarrhea, stopping fever, signs and symptoms relieved and clinical efficacy, adverse events of two group were compared. Results: Time duration of stopping diarrhea, stopping fever, signs and symptoms relieved of the observation group were less than the control group, the differences were statistically significant (P<0.05). The markedly effective rate of the observation group was 70.00%, the total effective rate was 93.33%. The markedly effective rate of the control group was 31.67%, the total effective rate was 70.00%, the markedly effective rate and the total effective rate of the observation group were higher than the control group, the differences were statistically significant (P<0.05). No serious adverse events were recorded in two groups. Conclusion: The clinical efficacy and safety of Zhili Granule is clear when treating the children with acute bacterial diarrhea, it takes less time to stop diarrhea, fever and other symptoms with less adverse effect and better effect, which is worthy of clinical application. |
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