| To observe the improvement effect of the ginkgo biloba extract on the cognitive function in the patients with senile dementia, and discuse its mechanism. Methods:A total of 80 senile dementia patients in our hospital during in January 2013-January 2014 were randomly divided into control group and observation group, 40 cases in each group. Both of the two groups orally took Donepezil HCL, once a day, 10 mg/time. The observation group additionally had ginkgo biloba extract injection on these basis, both two group had continuous treatment for 3 months and then compare the two groups’mini-mental state examination(MMSE), clock drawing task (CDT), activity of daily living (ADL) before treatment, and 1 month and 3 months after treatment, as well as detect two groups’concentration changes of iconic proteins cAMP, PKA and CREB in patients with peripheral serum cAMP-PKA-CREB signaling pathways before and after treatment. Results:1) Integral differences of MMSE, CDT and ADL were showed no statistical significance in the two groups after the treatment (P>0.05), the MMSE, CDT and ADL integral rose after 1 month’s treatment in the two groups (P<0.05), but there was no statistically significant differences between the two groups (P>0.05); and 3 months after treatment, MMSE, CDT, ADL integral of the two groups further improved, which the improvement extent of observation group was significantly higher than the control group, the differences were statistically significant (P<0.05). 2)The cAMP, PKA concentration detected by Elisa method, and CREB concentration by Western blotting test showed no statistically significant differences between the two groups (P>0.05), but 3 months after treatment, cAMP, PKA, and CREB protein concentrations in peripheral blood in the treatment group were significantly higher than that of control group (P<0.05). Conclusion:Ginkgo biloba extract can improve the cognitive ability in patients with senile dementia, the mechanism may be related to cAMP-PKA-CREB signaling pathways. |
