世界中医药

目的:观察复方斑蝥胶囊在改善肺癌患者免疫力方面的临床疗效,并借此探讨其对各炎性反应因子及免疫因子的影响和机制。方法:选取2015年8月至2016年6月南京军区福州总医院第一附属医院收治的非小细胞肺癌(NSCLC)患者患者90例,随机分成对照组和观察组,每组45例。观察组予口服复方斑蝥胶囊750 mg口服,3次/d,连用1周(7 d),对照组采用生理盐水250 mL静脉推注,2次/d,持续7 d。治疗7 d后观察2组治疗的临床疗效、各免疫因子评分、药物不良反应、临床受益情况分析及血浆IL-2、IL-6、IL-10及TNF-α水平变化等情况。结果:1)治疗后观察组有效率88.89%,对照组有效率77.78%,2组有效率比较差异有统计学意义(P<0.05);2)2组患者治疗前各免疫功能比较,差异无统计学意义(P>0.05),治疗7 d后,观察组各免疫动能均较治疗前稍提高,但对照组较治疗前无变化,差异有统计学意义(P<0.05);3)2组患者治疗过程中均出现不同程度的不良反应,比如可表现为腹痛、腹泻、恶心、呕吐等,对照组出现2例(4.44%),观察组2例(4.44%),观察组不良反应与对照组比,差异无统计学意义(P>0.05),该药不会增加患者用药不良反应。观察组KPS和体重变化的稳定率和改善例数明显高于对照组(P<0.05);4)2组患者治疗前血浆IL-2、IL-6、IL-10及TNF-α水平比较差异无统计学意义(P>0.05)。治疗7 d后,上述指标均较治疗前下降,但观察组下降更明显。结论:复方斑蝥胶囊在治疗肺癌患者免疫力低下方面的效果显著,并且不良反应作用小,性价比高,值得临床上全面推广。

English Summary:

To observe the effect of the Composite Blister Beetle Capsule in the treatment of perioperative lung cancer, and to discuss the regulation of immunity. Methods:A total of 90 perioperative lung cancer who were admitted to our department from August 2015-January 2016, were randomly divided into control group and observation group, 45 cases in each group. The control group, glucose injection 250 mL intravenous injection, twice a day for 15 days. Observation group were given Composite Blister Beetle Capsule twice a day. After 15 days’treatment, the clinical efficacy of the same treatment, all immune factors score, adverse drug reactions, clinical benefit analysis and serum IL-2, IL-6, IL-10 and TNF-α level changes were evaluated. Results:1）After the treatment, the observation group’s effective rate was 88.89％, the control group 77.78, the differences were statistically significant between the two groups(P<0.05)；2) Before treatment, comparison of each two groups of patients,’immune function has no statistically significant difference(P>0.05), after 15 days’treatment, observation group’s immunized kinetic energy slightly improved, but the treatment experienced no changes compared with the control group, the difference was statistically significant (P<0.05); 3) During the treatment, 2 groups of patients showed different adverse reactions, such as abdominal pain, diarrhea, nausea, vomiting, white blood cells, platelets, hemoglobin and reduction treatment. There was 1 case (4.44%) in control group, but two cases (4.44%) in observation group, the difference was not statistically significant, the drug does not increase side effects (P>0.05). The observation group has higher stability rate than control group in KPS and body weight change (P<0.05); 4) Before treatment, the comparison of two groups of patients in plasma IL-2, IL-6, IL-10 and TNF-α level showed no different (P>0.05). After 15 days’treatment, the index decreased, but the observation group decreased more significantly. Conclusion:Composite Blister Beetle Capsule can improve the immunity of lung cancer patients with significant clinical effect and not obvious side effect, which is worthy of clinical promotion.

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