| 引用本文:卿照前1，王松涛1，张国强2，谭秦湘3.芪参益气滴丸对糖尿病早期肾病患者血SSA、IL-6及TNF-α的影响[J].世界中医药,2016,(12):. |
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| 芪参益气滴丸对糖尿病早期肾病患者血SSA、IL-6及TNF-α的影响 |
| Effect of Ginseng and Astragalus Qi-Replenishing Drop Pill on Early Diabetic Nephropathy Patients’SSA, IL-6 and TNF-α levels |
| 投稿时间：2016-08-17 |
| DOI：10.3969/j.issn.1673-7202.2016.12.035 |
| 中文关键词: 芪参益气滴丸 糖尿病 早期肾病 |
| English Keywords:Ginseng and Astragalus Qi-Replenishing Drop Pill Diabetes Early stage Nephropathy |
| 基金项目:长沙市科技局资助项目(编号:K0902133-31) |
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| 中文摘要: |
| 目的:探讨芪参益气滴丸对糖尿病早期肾病患者血清淀粉样蛋白(SSA)、白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平的影响。方法:回顾性分析2012年9月至2015年12月期间长沙市中医医院确诊治疗的糖尿病早期肾病患者100例,依据治疗方法分为滴丸组和基础组,每组50例,基础组患者给予常规饮食控制、胰岛素降糖等基础治疗,滴丸组患者在此基础上给予500 mg芪参益气滴丸治疗,采用酶联免疫吸附法(ELISA)检测血清SSA、IL-6及TNF-α水平,随访6个月,统计分析所有患者治疗前后上述指标水平、治疗前、治疗后1、3、6个月尿β2微球蛋白(β2-MG)、尿白蛋白排泄率(UAER)和不良反应发生情况。结果:滴丸组患者治疗后血清SSA、IL-6及TNF-α水平明显低于基础组,差异有统计学意义(P<0.05);滴丸组患者治疗后1、3、6个月β2-MG、UAER水平低于基础组,差异有统计学意义(P<0.05);滴丸组和基础组患者均无不良反应发生。结论:芪参益气滴丸可有效改善糖尿病早期肾病患者炎性反应状态,减少患者尿白蛋白的排出,且具有良好的安全性,值得临床作进一步推广。 |
| English Summary: |
| To discuss the effect of Ginseng and Astragalus Qi-Replenishing Drop Pill on early diabetic nephropathy patients’serum amyloid protein(SSA), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) levels. Methods:Early diabetic nephropathy 100 patients were retrospectively analyzed from September 2012 to December 2015 in our Hospitals. According to the treatment, all patients were divided into pill group and control group, 50 cases in each group, control group patients were given regular diet control, insulin hypoglycemic therapy. On its basis, the pill group were given 500 mg of Ginseng and Astragalus Qi-Replenishing Drop Pill. The enzyme-linked immunosorbent (ELISA) was used to detect serum SSA, IL-6 and TNF-α level, followed up for 6 months. All patients’index levels, before and after treatment 1, 3, 6 months’urine beta 2 microglobulin (β2-MG), urinary albumin excretion rate (UAER) and adverse reactions were observed. Results:After the treatment, the pill group’s serum SSA, IL-6 and TNF-α level were significantly lower than the control group (P<0.05); Pill group patients’1, 3, 6 months β2-MG, UAER levels were significantly lower than the control group (P<0.05); Pill group and control group had no adverse reactions. Conclusion:Ginseng and Astragalus Qi-Replenishing Drop Pill can effectively improve the inflammatory state in patients with early diabetic nephropathy, reduce the excretion of urine albumin of patients with safety, which is worthy of further clinical promotion. |
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