| 引用本文:丁荣敏1，潘和蹇2，刘竞天1，刘雪梅1.消喘膏穴位贴敷治疗稳定期慢性阻塞性肺病的疗效及对患者气道炎性反应的影响[J].世界中医药,2016,(12):. |
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| 消喘膏穴位贴敷治疗稳定期慢性阻塞性肺病的疗效及对患者气道炎性反应的影响 |
| Efficacy of Xiao Chuan Paste Point Application in Stable Chronic Obstructive Pulmonary Disease and Effect on Airway inflammation |
| 投稿时间：2016-09-28 |
| DOI：10.3969/j.issn.1673-7202.2016.12.038 |
| 中文关键词: 慢性阻塞性肺病 穴位贴 消喘膏 肺功能 气道炎性反应 诱导痰 |
| English Keywords:Chronic obstructive pulmonary disease Point application Xiao Chuan paste Lung function Airway inflammation Induced sputum |
| 基金项目:吴门医药研究发展中心课题(编号:Wmyy201506);江苏高校哲学社会科学研究项目(编号:2014SJB598) |
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| 中文摘要: |
| 目的:探讨消喘膏穴位贴敷治疗稳定期慢性阻塞性肺病(COPD)患者的临床效果及对气道炎性反应因子的影响。方法:选取67例稳定期COPD患者随机分为对照组(n=33)和观察组(n=34),分别给予安慰剂及消喘膏贴敷治疗,2组均于夏季“三伏”贴治3次,连续治疗2年。统计2组中医临床症状疗效及治疗前后中医证候积分;治疗前及治疗1年、2年后,采用肺功能仪检测2组肺功能指标;分别于贴敷前及贴敷后6个月留取患者诱导痰样本,检测2组炎性细胞及相关炎性反应因子含量;统计2组患者治疗过程中感冒及急性发作情况。结果:观察组中医临床症状有效率为85.29%,显著高于对照组的63.64%;与治疗前比较,观察组治疗1年、2年后中医症候积分均显著降低(P<0.01),且显著低于对照组(P<0.05或P<0.01);治疗2年后观察组FEV1、FEV1/PR及FEV1/FVC较治疗前有所改善(P<0.05),但2组差异无统计学意义(P>0.05);治疗后观察组中性粒细胞比例、诱导痰上清中IL-8、LEP水平较治疗前显著降低,且显著低于对照组(P<0.01),而sIgA水平较治疗前升高且显著高于对照组(P<0.01),对照组治疗前后中性粒细胞比例、IL-8、LEP及sIgA水平无显著变化(P>0.05);治疗2年后观察组年均感冒次数、急性发作次数、急诊次数及住院次数减少,且显著低于对照组(P<0.05或P<0.01)。结论:消喘膏穴位贴敷治疗可显著改善稳定期COPD患者的肺功能,减轻气道局部炎性反应,增强气道黏膜保护作用,减少患者后期年均急性发作次数。 |
| English Summary: |
| To explore the efficacy of Xiao Chuan paste point application in the treatment of patients with stable chronic obstructive pulmonary disease (COPD) and influence on airway inflammation. Methods:All 67 cases of stationary phase COPD patients were randomly divided into a control group (n=33) and an observation group (n=34), which were treated with Placebo and Xiao Chuan paste point application respectively, 3 times in summer dog days, and for 2 years continuously. The TCM clinical symptoms efficacy and TCM syndrome integral before and after treatment were counted. The index of lung function detected with lung function detector before and one, two years after treatment. Induced sputum sample of 2 groups before and six months after point application were collected, detecting the content of inflammatory cells and inflammatory factors. Attack of cold and acute episodes during treatment of 2 groups were counted.Results:The rate of TCM clinical symptoms efficacy of observation group was 85.29%, which was higher than that of control group, 63.64%, (P<0.05). Compared with that before treatment, the TCM syndrome integral of observation group decreased significantly 1 and 2years after treatment (P<0.01), which was greatly lower than that of control group ( P<0.05 or P<0.01). The FEV1, FEV1/PR and FEV1/FVC of observation group improved after 2 years’treatment, compared with that before treatment (P<0.05), but there was no significant difference (P>0.05). The proportion of neutrophils, IL-8 and LEP levels of induced sputum supernatant in observation group decreased significantly after treatment (P<0.01), while sIgA levels increased and was significantly higher than that of the control group(P<0.01), and there were significant difference between 2 groups (P<0.01). There were no obvious change in the proportion of neutrophils, IL-8, LEP and sIgA levels in control group (P>0.05). The average frequency of cold, acute attack, emergency treatment and hospitalization in observation group decreased, which were lower than that of control group (P<0.05 or P<0.01). Conclusion:Xiao Chuan paste point application improves the lung function of stationary phase COPD patients, alleviates the airway local inflammation, strengthens airway mucosal protective effect, and reduces the later average annual frequency of acute attack. |
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