世界中医药

目的:观察尿毒症患者微炎状态及FGF23的表达及百令胶囊对其的影响。方法:将本院100例尿毒症患者纳入研究,随机分为对照组和观察,同时将同期健康体检50例设为健康组,观察3组临床生化指标、IL-6、FGF23水平的变化。结果:1)治疗前尿毒症患者平均动脉压、BUN,SCr,EsR、血磷水平较健康对照组患者明显升高(P<0.05),红细胞、血红蛋白及转铁蛋白明显低于健康对照组(P<0.05)。而上述指标在2组尿毒症患者之间差异无统计学意义(P>0.05)。经过一阶段治疗后2组患者临床生化指标均有不同程度的改善,其中使用百令胶囊的观察组患者改善的幅度较对照组明显,差异均有统计学意义(P<0.05)。2)2组患者治疗前IL-6、FGF23均高于正常水平,治疗后上述2种指标水平均有所下降,而其中百令胶囊组下降的趋势更明显。3)FGF23水平和IL-6浓度关系呈正相关性(r=0.242,P<0.01),FGF23与ALB及HDL水平均呈负相关关系(r1=-0.342,P1=0.01)及(r=-0.425,P<0.01)。结论:尿毒症患者外周血清FGF和IL-6表达水平明显上调;百令胶囊可能通过抑制IL-6表达改善尿毒症透析患者炎性反应状态;FGF23有可能成为尿毒症透析患者炎性反应状态早期诊断及干预的新靶点。

English Summary:

To observe the mild inflammation status and the expression of FGF23 in patients with uremia and Bailing capsule’s impact on it.Methods:Totally 100 cases of patients with uremia in our hospital were included into the study, randomly divided into the control group and the observation group. And 50 cases of healthy check-up in the same period were the healthy group. The clinical biochemical index, CRP, FGF23 levels changes of the three groups were observed. Results:1) Before the treatment, mean arterial pressure, BUN, SCr and EsR levels of the uremic patients increased significantly comparing to the healthy and control groups (P<0.05), erythrocyte, hemoglobin and transferrin significantly lower than healthy and controls groups (P<0.05). And the above indexes were with no statistically significant difference between the two groups of patients with uremia (P>0.05). After a period of treatment, the clinical biochemical indicators of patients in the two groups had different degrees of improvement. The observation group, which took Bailing capsules, had more obvious improvement than the control group, and the differences were statistically significant (P<0.05); 2) The IL-6 and FGF23 level of both groups before treatment were higher than normal levels, and both of the 2 levels decreased after treatment, but the downward trend of Bailing capsule group was more obvious. 3) The relationship between the concentration of FGF23 and IL-6 levels had positive correlation (r=0.242, P<0.01). FGF23 and ALB and HDL levels had negative correlation (r1=-0.342 P<0.01) and (r=-0.425, P<0.01) .Conclusion:The expression level of peripheral blood FGF and IL-6 in patients with uremia increased obviously; Bailing capsule may inhibit the expression of IL-6 to improve the status of inflammation in patients with uremia hemodialysis; FGF23 may become a new target for early diagnosis and intervention of inflammation in patients with uremia hemodialysis.

查看全文查看/发表评论下载PDF阅读器