| 引用本文:张新恒1，王丽2.银丹心脑通软胶囊辅助治疗急性脑梗死患者对血清hs-CRP、TNF-α和IL-6的影响及疗效观察[J].世界中医药,2016,(12):. |
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| 银丹心脑通软胶囊辅助治疗急性脑梗死患者对血清hs-CRP、TNF-α和IL-6的影响及疗效观察 |
| Yindanxinnaotong Capsule as Adjuvant Therapy in Acute Cerebral Infarction on Serum Hs-CRP, TNF-α and IL-6:A Clinical Observation |
| 投稿时间：2016-09-28 |
| DOI：10.3969/j.issn.1673-7202.2016.12.040 |
| 中文关键词: 急性脑梗死 炎性反应因子 银丹心脑通软胶囊 |
| English Keywords:Acute cerebral infarction Inflammatory factor Yindanxinnaotong capsule |
| 基金项目:安徽省自然科学基金面上项目(编号:1608085MH210) |
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| 中文摘要: |
| 目的:探讨银丹脑血通辅助治疗急性脑梗死患者的疗效,以及对血清hs-CRP、TNF-α和IL-6等炎性反应因子的影响。方法:随机选取2015年7月至2016年7月收治的70例急性脑梗死患者,采用随机数字表法分为研究组与对照组各35例。2组患者均给予常规基础治疗,并给予阿司匹林肠溶片口服,100 mg/次,1次/d;吡拉西坦口服,0.8 g/次,3次/d;以及依达拉奉注射液进行静脉滴注,30 mg/次,2次/d。其中,研究组在上述治疗方案的基础上,联用银丹心脑通软胶囊口服,3粒/次,3次/d。2组患者均治疗2周。对2组患者治疗前、治疗1周和2周时,进行血清hs-CRP、TNF-α和IL-6的水平检测,并评估其MESS评分和Barthel指数评分,进行组间疗效对比。结果:1)2组治疗1、2周的Barthel指数和MESS评分均有显著改善(P<0.05);但研究组的改善均明显优于对照组(P<0.05)。2)2组治疗1、2周时的血清 hs-CRP、TNF-α和IL-6水平均有显著下降(P<0.05);但研究组的3项指标均明显低于对照组(P<0.05)。3)研究组在治疗1周时的总有效率为68.6%,治疗2周时为85.7%,均显著高于对照组的54.3%和74.3%(P<0.05)。2组患者治疗期间,均未发生严重的不良药物事件。结论:银丹心脑通软胶囊对急性脑梗死患者的炎性损伤有一定的抑制作用,可有效改善患者的神经功能缺损症状,提高其日常生活活动能力。 |
| English Summary: |
| To investigate the efficacy of the treatment in patients with acute cerebral infarction with Yindanxinnaootong capsule, and the influence on serum hs-CRP, TNF-α and IL-6. Methods:Totally 70 cases of acute cerebral infarction were randomly collected from July-2016 to July 2015, and were randomly divided into a study group and a control group with 35 cases in each. Two groups of patients were given conventional treatment, and also Aspirin Enteric-coated Tablets orally, 100 mg each time, once per day; piracetam orally, 0.8 g each time, 3 times per day; edaravone injection, 30 mg each time, twice per day.Besides, the study group was combined with Yindanxinnaotong capsule, oral administration, 3 tablets, 3 times per day. Two groups of patients were treated for 2 weeks. The serum levels of hs-CRP, TNF-α and IL-6 were detected in two groups before treatment, after 1 week of treatment and 2 weeks, and the MESS score and Barthel index score were evaluated. Results:1) The Barthel index and MESS score of the two groups were significantly improved (P<0.05), but the improvement of the study group was significantly better than that of the control group. 2) The serum levels of hs-CRP, TNF-α and IL-6 were significantly decreased (P<0.05) in 1 and 2 weeks of treatment, but the 3 indexes in the study group were significantly lower than those of the control group (P<0.05). 3) The total effective rate of the study group at 1 week was 68.6% and 85.7% at 2 weeks, which was both significantly higher than that of the control group (54.3% and 74.3%) (P<0.05). There were no serious adverse drug events in the two groups during the treatment. Conclusion:Yindanxinnaotong capsule inhibits the inflammatory injury of acute cerebral infarction, and can effectively improve the patient’s neurological symptoms and function of pursuing daily activity. |
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