| 引用本文:汪正芳1，贾玉2，侯亚男1.疏肝健脾法治疗腹泻型肠易激综合征肝郁脾虚证的临床观察及对血清脑肠肽水平的影响[J].世界中医药,2016,(12):. |
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| 疏肝健脾法治疗腹泻型肠易激综合征肝郁脾虚证的临床观察及对血清脑肠肽水平的影响 |
| Clinical Observation on therapy of Soothing the Liver and Strengthening the Spleen in Diarrhea-Predominant Irritable Bowel Syndrome(IBS-D) of Liver Depression and Spleen Deficiency Syndrome and Its Influence on Serum Brain-gut Peptide Level |
| 投稿时间：2016-09-28 |
| DOI：10.3969/j.issn.1673-7202.2016.12.042 |
| 中文关键词: 肠易激综合征 疏肝健脾法 肝郁脾虚证 脑肠肽 |
| English Keywords:Irritable bowel syndrome Shuganjianpi therapy Liver depression and spleen deficiency syndrome Brain-gut peptide |
| 基金项目:国家自然科学基金青年项目(编号:81302949);北京市中医药科技发展资金项目(编号:JJ2014-35);北京市医院管理局“青苗”计划专项经费资助(编号:QML20150902) |
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| 中文摘要: |
| 目的:探讨疏肝健脾法治疗腹泻型肠易激综合征(IBS-D)肝郁脾虚证的临床效果及对血清脑肠肽水平的影响。方法:将70例IBS-D患者随机分为观察组(n=35)和对照组(n=35),对照组采用常规西药进行治疗,观察组在此基础上增加自制疏肝健脾汤进行治疗,2组均治疗4周。比较治疗前后2组血清5-羟色胺(5-HT)、降钙素基因相关肽(CGRP)、血清P物质(SP)及神经肽Y(NPY)水平及中医症状积分变化,统计2组临床有效率及复发情况。结果:治疗后,2组血清5-HT、CGRP、SP、NPY水平均较治疗前降低,且观察组低于对照组(P<0.01);2组临床各项症状积分均较治疗前降低,且观察组在腹痛、腹泻、腹胀及倦怠乏力方面改善情况较对照组明显(P<0.01);观察组治疗总有效率为91.42%显著高于对照组的71.42%(P<0.05);随访期间观察组复发2例(6.25%),对照组复发8例(32.00%),组间差异有统计学意义(P<0.05)。结论:疏肝健脾汤结合西药的综合治疗法显著降低IBS-D患者血清5-HT、CGRP、SP、NPY水平,改善患者临床症状,且复发率低,具有较好的临床疗效。 |
| English Summary: |
| To investigate the clinical effect of soothing the liver and strengthening the spleen therapy on diarrhea-predominant irritable bowel syndrome (IBS-D) of liver depression and spleen deficiency syndrome and its effect on serum brain-gut peptide level. Methods:Seventy patients with IBS-D were randomly divided into an observation group (n=35) and a control group (n=35). The control group was treated with conventional western medicine, and the observation group was provided additional self-made Shuganjianpi Decoction for treatment, both for 4 weeks. The levels of 5-serotonin (5-HT), calcitonin gene-related peptide (CGRP), serum substance (SP) and neuropeptide Y (NPY) in the 2 groups were compared before and after treatment, and the clinical effective rate and recurrence were analyzed. Results:After treatment, the level of serum 5-HT, CGRP, SP, NPY in both of the 2 groups were lower than before treatment, and those of the observation group was lower than those of the control group (P<0.01); The clinical symptoms integral of the 2 groups were lower than that before treatment, and the improvement of abdominal pain, diarrhea, abdominal distension and fatigue in the observation group were significantly gtreater than those in the control group (P<0.01); The total effective rate was 91.42% in the observation group, which was significantly higher than that in the control group (71.42%) (P<0.05). During follow-up, 2 cases (6.25%) relapsed in the observation group, while 8 (32%) in the control group and there was significant difference between the 2 groups (P<0.05). Conclusion:Shuganjianpi decoction combined with western medicine can significantly decrease the levels of serum 5-HT, CGRP, SP and NPY in patients with IBS-D, and improve clinical symptoms with a low relapse rate, showing good clinical efficacy. |
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