世界中医药

目的:探讨参附注射液对普外术后患者机体免疫功能和血液流变学指标的影响。方法:选取2015年6月至2016年9月我院普外科进行手术治疗的患者86例,并随机分为观察组(n=43)和对照组(n=43)。对照组采用普外手术围手术期常规治疗,观察组在对照组的基础上加用参附注射液治疗,均连续治疗7 d。检测并比较2组免疫功能、血液流变学指标及组织修复相关细胞因子水平变化。结果:与术前比较,术后对照组血清IgG、IgA及IgM水平,CD4+、CD8+细胞比例,CD4+/CD8+比值明显降低,而观察组血清IgG、IgA及IgM水平,CD4+细胞比例,CD4+/CD8+比值明显升高,且术后2组间差异有统计学意义(P<0.01)。术后对照组全血高/低切黏度、血浆黏度和纤维蛋白原升高(P<0.05或P<0.01),观察组全血低切黏度降低(P<0.05),其余指标均无显著变化(P<0.05),术后观察组全血高/低切黏度、血浆黏度和纤维蛋白原均低于对照组(P<0.05或P<0.01)。术后对照组SOD、MDA降低,TNF-α升高(P<0.01);而观察组仅SOD降低(P<0.01),MDA、TNF-α无显著变化(P>0.05);术后观察组SOD高于对照组,MDA、TNF-α低于对照组(P<0.01)。结论:参附注射液可提高普外手术患者术后免疫功能,降低血液流变学指标水平,减少手术对组织的损伤,有助于术后患者的恢复。

English Summary:

To investigate the effect of Shenfu Injection on the immune function of patients with general surgery and blood rheology.Methods:A total of 86 patients with Department of general surgery in our hospital from June 2015 to 2016 in were randomly divided into observation group(n=43)and control group(n=43).The control group with general surgery perioperative routine treatment,the observation group in the control group combined with Shenfu injection treatment,were treated for 7 d.The changes of immune function,hemorheology index and tissue repair related cytokines were detected and compared between the 2 groups.Results:compared with the preoperative control group,serum IgG,IgA and IgM levels after operation,the proportion of CD4+ cells,CD8+,and CD4+/CD8+ ratio decreased,and the observation group of serum IgG,IgA and IgM levels,CD4+ cell ratio,CD4+/CD8+ ratio was significantly increased,and after the difference between the 2 groups was significant(P<0.01).After the control group of whole blood high /low shear viscosity,plasma viscosity and fibrinogen(P<0.05 or P<0.01),the observation group of blood viscosity decreased(P<0.05),there were no significant changes in other indicators(P<0.05),postoperative observation group and high /low shear viscosity,plasma viscosity and fibrinogen were lower the control group(P<0.05 or P<0.01).The control group SOD,MDA decreased,TNF-α increased alpha(P<0.01); the observation group only decreased SOD(P<0.01),MDA,TNF-α alpha(P>0.05); no significant changes were observed after surgery in group SOD was higher than the control group,MDA,TNF-α were lower than that of the control group(P<0.01).Conclusion:Shenfu injection can improve the immune function in patients undergoing general surgery,reduce the level of blood rheology indexes,surgery to reduce tissue damage,contribute to the recovery of the patients after surgery.

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