To investigate the effect of Shenfu Injection on the immune function of patients with general surgery and blood rheology.Methods:A total of 86 patients with Department of general surgery in our hospital from June 2015 to 2016 in were randomly divided into observation group(n=43)and control group(n=43).The control group with general surgery perioperative routine treatment,the observation group in the control group combined with Shenfu injection treatment,were treated for 7 d.The changes of immune function,hemorheology index and tissue repair related cytokines were detected and compared between the 2 groups.Results:compared with the preoperative control group,serum IgG,IgA and IgM levels after operation,the proportion of CD4+ cells,CD8+,and CD4+/CD8+ ratio decreased,and the observation group of serum IgG,IgA and IgM levels,CD4+ cell ratio,CD4+/CD8+ ratio was significantly increased,and after the difference between the 2 groups was significant(P<0.01).After the control group of whole blood high /low shear viscosity,plasma viscosity and fibrinogen(P<0.05 or P<0.01),the observation group of blood viscosity decreased(P<0.05),there were no significant changes in other indicators(P<0.05),postoperative observation group and high /low shear viscosity,plasma viscosity and fibrinogen were lower the control group(P<0.05 or P<0.01).The control group SOD,MDA decreased,TNF-α increased alpha(P<0.01); the observation group only decreased SOD(P<0.01),MDA,TNF-α alpha(P>0.05); no significant changes were observed after surgery in group SOD was higher than the control group,MDA,TNF-α were lower than that of the control group(P<0.01).Conclusion:Shenfu injection can improve the immune function in patients undergoing general surgery,reduce the level of blood rheology indexes,surgery to reduce tissue damage,contribute to the recovery of the patients after surgery.