| 引用本文:黎伟文，黄代鸿，罗叶松，黄东海.参一胶囊对非小细胞肺癌术后生活质量影响的临床研究[J].世界中医药,2016,(12):. |
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| 参一胶囊对非小细胞肺癌术后生活质量影响的临床研究 |
| Clinical study on the effect of ginseng capsule on the quality of life of patients with non small cell lung cancer |
| 投稿时间：2016-11-03 |
| DOI：10.3969/j.issn.1673-7202.2016.12.049 |
| 中文关键词: 非小细胞肺癌 近期疗效 气虚证 生活质量 |
| English Keywords:NSCLC Short-term effects Syndrome of qi deficiency Quality of life |
| 基金项目:国家自然科学基金项目（编号：81172235）——晚期肺癌患者化疗和靶向治疗对外周血中EGFR-TKIs疗效相关的分子标志物检测的影响 |
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| 中文摘要: |
| 目的：观察参一胶囊对Ⅱ、Ⅲ期NSCLC术后不同群体化疗患者生活质量的影响。方法：采用随机对照方法，应用参一胶囊治疗Ⅱ、Ⅲ期NSCLC术后行4个疗程GP方案化疗并表现为气虚证患者2年，VEGF阳性组27例，VEGF阴性30例。比较肿瘤指标、气虚症候改善及生活质量评分。结果：参一胶囊能显著改善2组患者气虚证候，生活质量评分VEGF阳性组较VEGF阴性组高，2组差异有统计学意义，P<0.01；2年后评估发现VEGF阳性组肿瘤指标异常比例较VEGF阴性组低，2组比较差异有统计学意义，P<0.01。结论：参一胶囊能显著改善Ⅱ、Ⅲ期NSCLC术后化疗患者的气虚症候，延缓VEGF阳性患者的转移和复发，显著提高患者生活质量。 |
| English Summary: |
| To observe the effect of ginseng and one capsule on the quality of life of patients with different groups after NSCLC operation.Methods:Randomized controlled method was used in the research，application of Shen Yi Capsule in the treatment of NSCLC after surgery and after four courses of GP chemotherapy and the expression of qi deficiency syndrome in 2 years，the VEGF positive group was 27 cases，and 30 cases of VEGF negative.Comparison of tumor markers，Qi deficiency syndrome and quality of life score.Results:Shen Yi Capsule can significantly improve the two groups of patients with Qi deficiency syndrome，high quality of life score of VEGF positive group than in VEGF negative group，the two groups have significant difference，P<0.01; the assessment after two years found low proportion of abnormal tumor markers in VEGF positive group than VEGF negative group，two groups compared with significant difference(P<0.01).Conclusion:Shen Yi Capsule can significantly improve the syndrome of qi deficiency in patients with NSCLC after surgery，delay the metastasis and recurrence of VEGF positive patients，and significantly improve the quality of life of patients. |
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