To observe the effect of ginseng and one capsule on the quality of life of patients with different groups after NSCLC operation.Methods:Randomized controlled method was used in the research，application of Shen Yi Capsule in the treatment of NSCLC after surgery and after four courses of GP chemotherapy and the expression of qi deficiency syndrome in 2 years，the VEGF positive group was 27 cases，and 30 cases of VEGF negative.Comparison of tumor markers，Qi deficiency syndrome and quality of life score.Results:Shen Yi Capsule can significantly improve the two groups of patients with Qi deficiency syndrome，high quality of life score of VEGF positive group than in VEGF negative group，the two groups have significant difference，P<0.01; the assessment after two years found low proportion of abnormal tumor markers in VEGF positive group than VEGF negative group，two groups compared with significant difference(P<0.01).Conclusion:Shen Yi Capsule can significantly improve the syndrome of qi deficiency in patients with NSCLC after surgery，delay the metastasis and recurrence of VEGF positive patients，and significantly improve the quality of life of patients.