| 引用本文:辛大永，冯京帅.益气软坚消癥法提高气虚血瘀型特发性肺纤维化患者生活质量的临床研究[J].世界中医药,2016,(12):. |
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| 益气软坚消癥法提高气虚血瘀型特发性肺纤维化患者生活质量的临床研究 |
| Tonifying Qi, Softening Hardness and Eliminating Abdominal Mass to Improve Life of Patients of Idiopathic Pulmonary Fibrosis with Qi Deficiency and Blood Stasis:A Clinical study |
| 投稿时间：2016-10-25 |
| DOI：10.3969/j.issn.1673-7202.2016.12.050 |
| 中文关键词: 特发性肺纤维化 益气软坚消癥法 气虚血瘀 二甲消癥汤 圣·乔治评分 6分钟步行距离 中医症状积分 高分辨CT评分 |
| English Keywords:Idiopathic pulmonary fibrosis Tonifying qi, softening hardness and eliminating abdominal mass method Qi deficiency and blood stasis Erjiaxiaozheng decoction St George’s respiratory questionnaire scores 6-minute walking distance Chinese symptom scores High resolution CT scores |
| 基金项目:北京中医药科技发展资金项目（编号：JJ2015-26） |
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| 中文摘要: |
| 目的：探讨益气软坚消癥法（二甲消癥汤）对气虚血瘀型特发性肺纤维化（IPF）患者的治疗效果。方法：收集2014年1月至2016年1月的IPF患者49例，将其随机分为2组，治疗组25例予二甲消癥汤口服，对照组24例予乙酰半胱氨酸胶囊口服，疗程3个月，随访3个月，观察2组治疗前后及随访期圣·乔治评分（SGRQ评分）、6 min步行距离（6MWD）、中医症状积分、高分辨CT评分（HRCT）变化，及2组之间的差异。结果:治疗组在治疗3个月及随访3个月后，SGRQ评分、6WMD、中医症状积分方面与治疗前差异均有统计学意义（P<0.05）；而对照组6MWD在治疗前与治疗3个月后、随访3个月后差异有统计学意义（P<0.05），其余差异均无统计学意义（P>0.05）。2组的HRCT积分均无改善。结论:二甲消癥汤能够改善特发性肺间质纤维化患者的生活质量，消除中医症状，均优于乙酰半胱氨酸组，且能够较好的维持。而治疗组及对照组均能增加患者的6MWD，治疗组优于对照组，但不能较好的维持。 |
| English Summary: |
| To investigate efficacy of tonifying qi, softening hardness and eliminating abdominal mass method (Erjiaxiaozheng decoction) on treatment of idiopathic pulmonary fibrosis with qi deficiency and blood stasis. Methods:Collecting 49 cases of IPF from January 2015 to December 2016,we divided all the patients into two groups:the treatment group (treated with Erjiaxiaozheng decoction)，and the control group (treated with Acetylcysteine).Thus we mainly observed and assessed such indexes as St George’s respiratory questionnaire scores, 6-minute walking distance, Chinese medicine symptom scores and high resolution CT scores before treatment, 3 months after treatment and another later 3 months of following up. Results:Data above were evaluated:in treatment group, St George’s respiratory questionnaire scores, 6-minute walking distance, Chinese symptom scores of 3 months after treatment and after another later 3 months of following up showed statistical difference (P<0.05); in the control group, 6WMD before treatment, 3 months after treatment and after another later 3 months of following up showed statistical difference (P<0.05), while others did not (P>0.05). And there was no statistical difference in High Resolution CT between two groups. Conclusion:Erjixiozheng decoction can improve life of idiopathic pulmonary fibrosis with qi deficiency and blood stasis patients, eliminate Chinese medical symptoms with long-time efficacy, which is better than control group. Both of the two groups increased 6MWD, treatment group better but does not last. |
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