| 引用本文:杨涛1，李潇然1，王世东2,3，肖永华2，赵进喜2，倪博然1，陈默1，吕仁和2，李佳玥2，韩媛媛2，李彤2.活血消癥中药治疗糖尿病肾病的随机对照临床试验系统综述及Meta分析[J].世界中医药,2017,(01):. |
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| 活血消癥中药治疗糖尿病肾病的随机对照临床试验系统综述及Meta分析 |
| Randomized Controlled Clinical Trial of Blood-activating and Stasis-resolving Herbs in Treatment of DN：A Systematic Review and Meta-Analysis |
| 投稿时间：2016-12-20 |
| DOI：10.3969/j.issn.1673-7202.2017.01.002 |
| 中文关键词: 活血消癥中药 糖尿病肾病 系统综述 Meta分析 |
| English Keywords:Blood-activating and stasis-resolving herbs Diabetic nephropathy Systematic review Meta-Analysis |
| 基金项目:北京市“十病十方”科技攻关项目；国家中医临床研究基地重点病种专项研究 |
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| 中文摘要: |
| 目的：探讨活血消癥中药辨证治疗糖尿病肾病（Diabetic Nephropathy，DN）的有效性及安全性。方法：检索5个主要的电子数据库（中文数据库：中国知网（CNKI）、万方、维普（VIP），英文数据库：Medline、CENTRAL），检索日期从建库至2016年7月。筛选纳入并Meta分析活血消癥中药治疗DN的随机对照试验(Randomized Controlled Trials，RCT)。结果：活血消癥中药对于改善患者24 h尿蛋白定量（quantitative test of 24 h urinary protein，24 hUTP）（MD=-0.08 g，95%CI＝［-0.13,-0.03］，I2=0%）和中医证候积分（MD=-3.82，95%CI=［-4.84,-2.79］，I2=0%）疗效优于ACEI/ARB类药物。对于SCr和BUN的影响，组间差异无统计学意义。结论：活血消癥中药降低DN患者24 hUTP和改善临床症状疗效优于ACEI/ARB类药物。 |
| English Summary: |
| To explore the efficacy and safety of blood-activating and stasis-resolving herbs in treatment of diabetic nephropathy (DN).Methods:A total of 5 major electronic databases were retrieved.Chinese databases include：CNKI，Wan Fang database，VIP database，English databases include：Medline，CENTRAL.Retrieve the date from inception date to July 2016.Meta-Analysis was used to analyze the randomized controlled trials (RCTs) in Chinese herbal medicine therapy for DN.Results:Blood-activating and stasis-resolving herbs is better than ACEI/ARB in improving 24 hUTP (MD＝-0.08 g，95%CI=［-0.13，-0.03］，I2=0%)and TCM syndrome scores (MD＝-3.82，95%CI=［-4.84，-2.79］，I2=0%).For the effects of SCr and BUN，there were no significant differences between the groups.Conclusion:Blood-activating and stasis-resolving herbs to reduce DN patients′ 24 hUTP and improve clinical symptoms is better than ACEI/ARB. |
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