世界中医药

作者	单位
王海雄1，桑志成1,2，温建民1，闫立1，孙永生1，胡海威1	1 中国中医科学院望京医院骨关节二科，北京，100102； 2 中国中医科学院博士后科研流动站，北京，100700

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中文摘要:

目的：评价补肾健脾方内服治疗重度膝骨关节炎（KOA）的临床疗效。方法：将60例重度KOA患者随机分为治疗组32例对照组28例。对照组采用健康教育、功能锻炼及药物洛索洛芬钠片和盐酸氨基葡萄糖胶囊口服，治疗组在对照组基础上加用补肾健脾方内服。2组均以2周为1个疗程。同时采用WOMAC骨性关节炎指数量表及ISOA膝骨关节炎严重程度指数量表在治疗前后进行评分，并根据评分下降比例评价疗效。结果：根据WOMAC量表评价疗效，治疗组总有效率为78.13%，对照组为53.57%，根据ISOA量表，2组有效率分别为81.25%、78.57%。2组患者症状及体征、最大步行距离及日常生活难度评分治疗后均较治疗前明显下降,差异均有统计学意义（P<0.01）；治疗后组间比较,最大步行距离评分治疗组优于对照组，差异有统计学意义（P>0.05）。结论：补肾健脾方内服能有效改善膝重度骨关节炎病情。

English Summary:

To evaluate the clinical effect of Bushen Jianpi prescription in the treatment of severe osteoarthritis of the knee (KOA). Method:Sixty patients with severe KOA were randomly divided into treatment group and control group, with 32 cases in treatment group and 28 cases in control group. The control group was given health education, functional exercise, loxoprofen sodium tablets and glucosamine hydrochloride capsules orally, while the treatment group was orally given Bushen Jianpi prescription. The treatment lasted 2 weeks. The WOMAC scale and ISOA scale were used to score the disease before and after treatment, and the effect was evaluated according to the decline proportion of the score. Results:According to the WOMAC rating, the total effective rate was 78.13% in the treatment group, and that of the control group was 53.57%. According to the ISOA scale, the efficiency of the two groups was 81.25% and 78.57% respectively. The scores of symptoms and signs, maximum walking distance and the daily life were significantly decreased after treatment(P<0.01). After treatment, the maximum walking distance score in the treatment group was superior to that of the control group(P<0.05). Conclusion:Bushen Jianpi prescription can effectively improve the severe KOA symptoms.

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