| 引用本文:单自琴，许剑婕.瓜蒌薤白半夏汤加减治疗冠心病心绞痛痰浊痹阻证对于心肌血运重建的影响[J].世界中医药,2017,(01):. |
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| 瓜蒌薤白半夏汤加减治疗冠心病心绞痛痰浊痹阻证对于心肌血运重建的影响 |
| Effects of Gualou Xiebai Banxia Decoction Myocardial Revascularizationin the Treatment of Angina Pectoris of Coronary Heart Disease of Phlegm Stagnation Syndrome |
| 投稿时间：2016-03-29 |
| DOI：10.3969/j.issn.1673-7202.2017.01.013 |
| 中文关键词: 瓜蒌薤白半夏汤 冠心病心绞痛 痰浊痹阻证 心肌血运重建 内皮细胞分化功能 |
| English Keywords:GualouXiebaiBanxia Decoction Angina pectoris Phlegm stagnation syndrome Myocardial revascularization Endothelial cells function |
| 基金项目:北京市顺义区科技计划项目(编号：201501) |
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| 目的：探讨瓜蒌薤白半夏汤加减治疗冠心病心绞痛痰浊痹阻证对于心肌血运重建的影响。方法：选择2013年6月至2015年12月在我院住院的182例冠心病心绞痛痰浊痹阻证患者，采用简单随机分组法分为对照组和观察组各91例，对照组给予常规西药治疗，在此基础上治疗组加用瓜蒌薤白半夏汤加减治疗，都治疗观察14 d。结果：治疗后观察组的总有效率（97.8%）明显高于对照组86.8%）(P<0.05)。观察组与对照组治疗后的硝酸甘油用量分别为（6.87±2.45）mL和（8.45±2.87）mL，都明显低于治疗前的（12.84±3.09）mL和（12.67±2.89）mL(P<0.05)，同时观察组治疗后的硝酸甘油用量也明显少于对照组(P<0.05)。2组治疗后的加压后肱动脉内径扩张率都明显增加，在组内与组间对比差异都有统计学意义(P<0.05)，2组治疗前后的静息状态肱动脉内径在组内与组间对比差异无统计学意义(P>0.05)。观察组治疗后的左室前壁中间段的b值与k值分别为（5.45±0.76）db和（1.88±0.25）S′，而对照组分别为（5.02±0.56）db和（1.80±0.21）S′，观察组都明显高于对照组(P<0.05)，且2组的组内对比差异都有统计学意义(P<0.05)。结论：瓜蒌薤白半夏汤加减治疗冠心病心绞痛痰浊痹阻证能逆转内皮细胞分化功能，促进心肌血运重建的改善，从而减少硝酸甘油的用量，提高总体治疗效果。 |
| English Summary: |
| To observe the effects of GualouXiebaiBanxia decoction on myocardial revascularization in the treatment of angina pectoris of coronary heart disease and phlegm stagnation syndrome. Methods:A total of 182 cases of angina pectoris of coronary heart disease of phlegm stagnation syndrome hospitalized in our hospital from June 2013 to December 2015 were collected, then equally divided into control group and observation group with 91 patients in each. The control group was given conventional western medicine treatment, on the basis of that, the treatment group were given Gualou Xiebai Banxia decoction. Treatment duration in the two groups were 14 d. Results:After treatment, the total effective rates in the observation group and the control group were 97.8% and 86.8%, and that of the observation group was significantly higher than that of the control group (P<0.05). The dosage of nitroglycerin in the observation group and the control group after treatment were 6.87 ± 2.45 mL and 8.45 ± 2.87 mL, significantly lower than before treatment (12.84 ± 3.09 mL and 12.67 ± 2.89 mL) respectively (P<0.05), while the dosage of nitroglycerin in the observation group after treatment were significantly lower than the control group (P<0.05). After treatment, the compression of brachial artery diameter expansion rates in the two groups were increased significantly, there were statistically significant growth difference in the group, besides, the difference between the two groups was significant (P<0.05). There were no significant difference in resting brachial artery diameter before and after treatment within the two groups (P>0.05). The left ventricular anterior wall of the middle section of the B and K values in the observation group after treatment were 5.45 ± 0.76 db and 1.88 ± 0.25 S′. While the control group were 5.02 ±0.56 db and 1.80 ± 0.21 S′， which is significantly higher than that of the control group (P<0.05). Conclusion:Gualou Xiebai Banxia decoction in the treatment of angina pectoris of coronary heart disease of phlegm stagnation syndrome can reverse differentiation of endothelial cell function, promote myocardial revascularization to improve, thereby reducing the dosage of nitroglycerin and improving the treatment effect. |
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