| 引用本文:曹兵1，丁奇2，刘熙鹏1，刘春江1，乔建新1.大株红景天注射液治疗大面积脑梗死的临床研究[J].世界中医药,2017,(01):. |
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| 大株红景天注射液治疗大面积脑梗死的临床研究 |
| Clinical studies of Sofren injection on treatment with Massive Cerebral Infarction |
| 投稿时间：2016-12-10 |
| DOI：10.3969/j.issn.1673-7202.2017.01.020 |
| 中文关键词: 大株红景天注射液 大面积脑梗死 临床研究 |
| English Keywords:Sofren injection Massive cerebral infarction Clinical studies |
| 基金项目:张家口市2014年度科学技术研究与发展指导计划项目（编号：1421120D） |
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| 中文摘要: |
| 目的：探讨大株红景天注射液治疗大面积脑梗死的临床疗效，为其治疗提供参考。方法：选择2014至2015年间我院经颅脑CT和（或）MRI诊断为大面积脑梗死的住院患者60例。随机分为对照组和观察组，每组30例。对照组患者给予常规治疗，包括脱水降颅压、抗血小板聚集、神经营养剂等，同时控制血压、血糖、血脂。观察组在对照组基础给予大株红景天注射液。治疗1个疗程后，观察2组病死率、临床疗效、血液流变学变化、氧化损伤指标、影像学指标和安全性。结果：观察组死亡率为13.33%，对照组30.00%，但是差异无统计学意义（χ2=2.45；P>0.05）。观察组患者治疗总有效率达66.67%，对照组33.37%，差异有统计学意义（P<0.05）。观察组患者血液流学指标全血比黏度、纤维蛋白原、血浆比黏度、红细胞压积水平均显著低于对照组，差异有统计学意义（P<0.05）。观察组SOD水平显著高于对照组，MDA水平显著低于对照组。且2组无严重不良反应，安全性高。结论：大株红景天注射液治疗大面积脑梗死的临床疗效肯定，值得临床推广。 |
| English Summary: |
| To explore the clinical studies of Sofren injection on treatment with massive cerebral infarction,provide reference for its treatment.Methods:A total of 60 patients with massive cerebral infarction,were randomly divided into control group and observation group,30 cases in each group.The control group were treated by conventional therapy,Including the dehydration of intracraninal pressure，platelet aggregation，neurotrophic agent，etc，at the same time control of blood pressure，blood sugar，blood fat.Observation group was given conventional treatment and Sofren injection.After one course of treatment,case fatality rate，clinical curative effect，hemorheology changes,oxidative damage change，Imaging changes and security of two groups were observed.Results:Observation group mortality was 13.33%，control group was 30.00%，but there was no statistically significant difference（χ2=2.45；P>0.05）.Observation group of patients treatment the total effective rate was 66.67%，significantly higher than the control group 33.37%（P<0.05）.Observation group of patients than whole blood viscosity，fibrinogen，plasma specific viscosity，erythrocyte pressure water，significantly lower than the control group，the difference was statistically significant（P<0.05）.Observation group with SOD were significantly higher than control group，the MDA level were significantly lower the control group（P<0.05）.No serious adverse reaction in both groups，high safety.Conclusion:The Sofren injection on treatment with massive cerebral infarction effect is good,worth clinical promotion. |
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