| 引用本文:汪正芳1，贾玉2，侯亚男3.健脾调肝温肾方干预对腹泻型IBS患者血清炎性反应因子及5-羟色胺的影响[J].世界中医药,2017,(01):. |
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| 健脾调肝温肾方干预对腹泻型IBS患者血清炎性反应因子及5-羟色胺的影响 |
| Effects of Jianpi Tiaogan Wenshen Formula on Serum Inflammatory Factors and 5-Hydroxytryptamine in Diarrhea Type IBS |
| 投稿时间：2016-11-21 |
| DOI：10.3969/j.issn.1673-7202.2017.01.029 |
| 中文关键词: 健脾调肝温肾方 腹泻型肠易激综合征 5-羟色胺 炎性反应因子 免疫功能 |
| English Keywords:Jianpi Tiaogan Wenshen Formula IBS-D 5-HT Inflammatory factor Immune function |
| 基金项目:国家自然科学基金青年项目(编号:81302949);北京市中医药科技发展资金项目(编号:JJ2014-35);北京市医院管理局“青苗”计划专项经费资助(编号:QML20150902) |
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| 中文摘要: |
| 目的:观察健脾调肝温肾方治疗腹泻型肠易激综合征(IBS-D)的临床疗效及对患者血生化指标的影响。方法:选取2015年2月至2016年3月首都医科大学附属北京中医医院收治的IBS-D患者122例,随机分为中医组(n=61)和西医组(n=61)。中医组给予健脾调肝温肾方并随证加减治疗,西医组给予匹维溴铵片口服治疗,2组均连续治疗4周。采用VAS量表评价2组患者治疗前后腹痛程度,检测并比较治疗前后2组患者血清炎性反应因子、免疫功能、胃肠激素、脑肠肽指标水平和肠黏膜MC数量变化。结果:治疗后2组IFN-γ、IL-8及IL-12水平、CD8+T细胞比例、MOT及GAS水平、5-HT及SP水平、VAS评分、大便性状评分及MC数量较治疗前均显著下降,IL-10、CD3+、CD4+及CD4+/CD8+T细胞比例、VIP、CCK及CGRP水平较治疗前显著上升(P<0.05或P<0.01),且组间差异有统计学意义(P<0.05或P<0.01)。结论:健脾调肝温肾方可显著改善IBS-D患者胃肠蠕动功能,平衡机体炎性反应因子水平,降低肠黏膜内MC数量并有效减少5-HT释放,进而缓解临床症状,疗效显著,值得临床推广应用。 |
| English Summary: |
| To observe the clinical effects of Jianpi Tiaogan Wenshen Formula on IBS-D and influence on blood biochemical index.Methods:A total of 122 cases of IBS-D were randomly divided into traditional Chinese medicine group (n=61) and Western medicine group (n=61).The Chinese medicine group was treated with Jianpi Tiaogan Wenshen Formula，the western medicine group were given pinaverium bromide tablets.Two groups were treated for four weeks.VAS scale was used to evaluate the degree of abdominal pain before and after treatment，the serum levels of inflammatory cytokines，immune function，gastrointestinal hormones，brain-gut peptide and intestinal mucosal MC were measured before and after treatment.Results:After treatment，the levels of IFN-γ，IL-8，IL-12，CD8+ T cells，MOT，GAS，5-HT，SP，VAS score，stool character score and MC numbers significantly decreased，IL-10，CD3+，CD4+，CD4+/CD8+ T cell ratio，VIP，CCK and CGRP levels significantly increased (P<0.05 or P<0.01)，and there were significant differences between the two groups (P<0.05 or P<0.01).Conclusion:Jianpi Tiaogan Wenshen Formula can significantly improve the gastrointestinal peristaltic function of IBS-D patients，balance the levels of inflammatory cytokines in body，reduce the number of MC in intestinal mucosa and the release of 5-HT，then alleviate the clinical symptoms，the curative effect is remarkable，which is worthy of clinical application. |
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