| 引用本文:李爱勇，张玉灵，邢文龙，尚菊菊，刘红旭.参元益气活血胶囊对不稳定型心绞痛气虚血瘀证患者择期PCI围术期ACE2的影响[J].世界中医药,2017,(02):. |
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| 参元益气活血胶囊对不稳定型心绞痛气虚血瘀证患者择期PCI围术期ACE2的影响 |
| Shenyuan Yiqi Huoxue Capsule on ACE2 of Patients with Unstable Angina of Qi-deficiency and Blood-stagnation Syndrome after PCI in Preoperative Period |
| 投稿时间：2017-02-10 |
| DOI：10.3969/j.issn.1673-7202.2017.02.002 |
| 中文关键词: 不稳定性心绞痛 参元益气活血胶囊 经皮冠状动脉介入 围术期心肌损伤 ACE2 |
| English Keywords:Unstable angina Shenyuan Yiqi Huoxue capsule PCI Perioperative period of myocardial damage ACE2 |
| 基金项目:北京市自然科学基金项目（编号：7142077）；北京市科委首都特色一般项目（编号：Z131107002213152） |
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| 中文摘要: |
| 目的：观察参元益气活血胶囊对择期经皮冠状动脉介入（PCI）气虚血瘀者患者围术期ACE2的影响，探讨该药的临床新用途。方法：采用前瞻性、随机、双盲、安慰剂、对照的临床试验方案观察对照组及观察组对择期PCI的不稳定型心绞痛（UA）患者血清中ACE2、ERK、PKC水平的影响，同时观察参元益气活血胶囊对择期PCI围术期心绞痛的临床疗效。结果：2组PCI术前ACE2、ERK、PKC差异无统计学意义（P>0.05）；对照组术后血清中ACE2、ERK、PKC水平有所升高，提示存在一定的围术期心肌损伤；观察组术后血清中ACE2、ERK、PKC水平较术前水平升高，与对照组比较差异有统计学意义（P<0.05）。2组患者PCI术后心绞痛发作均明显减少，显效率相当，总有效率观察组略高，但差异无统计学意义（P>0.05）。结论：参元益气活血胶囊对择期PCI围术期心肌损伤具有一定的保护作用。 |
| English Summary: |
| To observe the effect of Shenyuan Yiqi Huoxue capsule on ACE2 of patients with unstable angina(UA) of Qi-deficiency and Blood-stagnation syndrome after PCI in preoperative period,and explore its potential.Methods:Conduct RCTs in perspective with placebo to observe the ACE2,ERK,PKC level in the serum of patients with UA,thus studying the clinical effect of Shenyuan Yiqi Huoxue capsule.Results:Before the treatment,no statistical significance were found between the two groups in ACE2,ERK,PKC(P>0.05).While after the treatment there are significant difference in all those three levels in the treatment group and between the two groups(P<0.05).There being a rise of levels of all three in the control group after the surgery signifies myocardial damage.However,the occurrence of angina decreased in both groups after treatment,implying effectiveness; only without statistically higher total effective rate of the treatment group (P>0.05).Conclusion:Shenyuan Yiqi Huoxue capsule has effect on myocardial damage after PCI. |
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