| 引用本文:徐涛1，郝丽梅1，张焱2，刘长春1，刘红旭3.木丹颗粒联合甲钴胺治疗糖尿病周围神经病变的临床疗效[J].世界中医药,2017,(02):. |
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| 木丹颗粒联合甲钴胺治疗糖尿病周围神经病变的临床疗效 |
| The Effect of Mudan Granule combined with Macobalamine in the Treatment of Diabetic Peripheral Neuropathy |
| 投稿时间：2017-02-10 |
| DOI：10.3969/j.issn.1673-7202.2017.02.007 |
| 中文关键词: 糖尿病周围神经病变 木丹颗粒 甲钴胺 临床疗效 |
| English Keywords:Diabetic peripheral neuropathy Mudan Granule Macobalamine Clinical effect |
| 基金项目:首都医科大学附属北京中医医院脑心同治实验室项目（编号：20170101） |
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| 中文摘要: |
| 目的:观察木丹颗粒联合甲钴胺治疗糖尿病周围神经病变的临床疗效。方法:将2015年7月至2015年12月在我院神经内科门诊就诊的50例2型糖尿病并发糖尿病周围神经病变的患者，按随机数字表分为对照组及治疗组，每组各25例，2组患者均进行饮食、运动及常规降糖药物等基础治疗，对照组的药物主要为甲钴胺。治疗组同时给予甲钴胺和木丹颗粒治疗，连服12周。记录2组患者治疗前、治疗后的神经传导速度、TCSS评分、VAS和TSS评分；血浆纤维蛋白原及肝肾功能指标，判定临床总有效率。结果：治疗后，治疗组TCSS、TSS评分及刺痛、感觉减退、烧灼感VAS评分均明显改善，正中神经的感觉传导速度明显提高，血浆纤维蛋白原显著降低，与对照组相比差异有统计学意义(P<0.05)，治疗组的治疗总有效率亦显著高于对照组(P<0.05)。结论：木丹颗粒联合甲钴胺治疗糖尿病周围神经病变，可有效改善临床症状，尤其对刺痛及烧灼症状，提高患者的生活质量，安且全可靠，值得临床推广使用。 |
| English Summary: |
| To observe the clinical effect of Mudan Granule combined with macobalamine in treating diabetic peripheral neuropathy(DPN).Methods:Fifty cases of diabetes II patients admitted in our hospital from July 2015 to December 2015 were collected and randomly divided into control group and treatment group,with 25 cases in each.Basic treatment including dietary regulation and regular medication were given to both groups,only with the difference of major medicine(Mudan Granule and macobalamine in the treatment group and macobalamine in the control group).Treatment lasted for 12 weeks.Nerve conductive velocity(NCT),TCSS,VAS,and TSS were recorded before and after treatment.Also,serum fibrinogen and liver and kidney function indices were recorded to access the total effective rate.Results:After treatment,the scores of TCSS,TSS and VAS in stabbing pain,loss of sensation and burning pain were significantly improved in the treatment group,along with NCT and the level of serum fibrinogen.Comparing with the control group,the improvement is statistically significant(P<0.05).In addition,the total effective rate is significantly higher than that of the control group(P<0.05).Conclusion:Mudan Granule combined with macobalamine has a significant effect on relieving DPN symptoms especially in stabbing and burning pain-reliving.It can improve the living quality of patients,also secure and reliable,which can be promoted in clinical practice. |
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